Portal de investigação
Association between postnatal growth and neurodevelopmental impairment by sex at 2 years of corrected age in a multi-national cohort of very preterm children
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- El Rafei, R
- Jarreau, PH
- Norman, M
- Maier, RF
- Van Reempts, P
- Pedersen, P
- Cuttini, M
- Costa, R
- Zemlin, M
- Draper, ES
- Zeitlin, J
- EPICE Res Grp
Unidades de investigação
Abstract
Background & aims: Extra-uterine growth restriction (EUGR) is common among very preterm (VPT) infants and has been associated with impaired neurodevelopment. Some research suggests that adverse effects of EUGR may be more severe in boys. We investigated EUGR and neurodevelopment at 2 years of corrected age (CA) by sex in a VPT birth cohort. Methods: Data come from a population-based cohort of children born <32 weeks' gestation from 11 European countries and followed up at 2 years CA. Postnatal growth during the neonatal hospitalization was measured with: (1) birthweight and discharge-weight Z-score differences using Fenton charts (2) weight-gain velocity using Patel's model. Published cut-offs were used to define EUGR as none, moderate or severe. Neurodevelopmental impairment was assessed using a parent-report questionnaire, with standardized questions/instruments on motor function, vision, hearing and non-verbal cognition. We estimated relative risks (RR) adjusting for maternal and neonatal characteristics overall and by sex. Results: Among 4197 infants, the prevalence of moderate to severe impairment at 2 years CA was 17.7%. Severe EUGR was associated with neurodevelopmental impairment in the overall sample and the interaction with sex was significant. For boys, adjusted RR were 1.57 (95% Confidence Intervals (CI): 1.18 -2.09) for Fenton's delta Z-score and 1.50 (95% CI: 1.12-2.01) for Patel's weight-gain velocity, while for girls they were 0.97 (0.76-1.22) and 1.12 (0.90-1.40) respectively.
Dados da publicação
- ISSN/ISSNe:
- 1532-1983, 0261-5614
- Tipo:
- Article
- Páginas:
- 4948-4955
Clinical Nutrition Churchill Livingstone
Citações Recebidas na Web of Science: 11
Documentos
- Não há documentos
Filiações
Keywords
- Extrauterine growth restriction; Neurodevelopmental impairment; Very preterm infants; Suboptimal growth
Financiamento
Proyectos asociados
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
El Rafei R,Jarreau PH,Norman M,Maier RF,Barros H,Van P,Pedersen P,Cuttini M,Costa R,Zemlin M,Draper ES,Zeitlin J,EPICE GRP. Association between postnatal growth and neurodevelopmental impairment by sex at 2 years of corrected age in a multi-national cohort of very preterm children. Clin. Nutr. 2021. 40. (8):p. 4948-4955. IF:7,643. (1).
