Portal de investigação
Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Vitelli-Storelli, F
- Rubín-García, M
- Pelucchi, C
- Benavente, Y
- Bonzi, R
- Rota, M
- Palli, D
- Ferraroni, M
- Morais, S
- Ye, WM
- Plymoth, A
- Malekzadeh, R
- Tsugane, S
- Hidaka, A
- Aragonés, N
- Castaño-Vinyals, G
- Zaridze, DG
- Maximovich, D
- Vioque, J
- García-de-la-Hera, M
- Zhang, ZF
- Hamada, GS
- Pakseresht, M
- Pourfarzi, F
- Mu, LN
- Boccia, S
- Pastorino, R
- Yu, GP
- Lagiou, A
- Lagiou, P
- Negri, E
- La Vecchia, C
- Martín, V
Unidades de investigação
Abstract
Simple Summary Research is still required to establish the relationship between family history (FH) and gastric cancer (GC) in relation to different histological types and anatomical sites. The present work aimed to examine the influence of first-degree FH on the risk of GC, also according to the GC location and histological type, including 5946 cases and 12,776 controls from 17 studies of 11 countries in three continents participating in the Stomach Cancer Pooling (StoP) Project consortium. This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 controls from 17 studies of the Stomach Cancer Pooling (StoP) Project consortium. Summary odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were calculated by pooling study-specific ORs using fixed-effect model meta-analysis techniques. Stratified analyses were carried out by sex, age, tumor location and histological type, smoking habit, socioeconomic status, alcohol intake and fruit consumption. The pooled OR for GC was 1.84 (95% CI: 1.64-2.04; I2 = 6.1%, P heterogeneity = 0.383) in subjects with vs. those without first-degree relatives with GC. No significant differences were observed among subgroups of sex, age, geographic area or study period. Associations tended to be stronger for non-cardia (OR = 1.82; 95% CI: 1.59-2.05 for subjects with FH) than for cardia GC (OR = 1.38; 95% CI: 0.98-1.77), and for the intestinal (OR = 1.92; 95% CI: 1.62-2.23) than for the diffuse histotype (OR = 1.62; 95% CI: 1.28-1.96). This analysis confirms the effect of FH on the risk of GC, reporting an approximately doubled risk, and provides further quantification of the risk of GC according to the subsite and histotype. Considering these findings, accounting for the presence of FH to carry out correct prevention and diagnosis measures is of the utmost importance.
Dados da publicação
- ISSN/ISSNe:
- 2072-6694, 2072-6694
- Tipo:
- Article
- Páginas:
- 3844-
- Link para outro recurso:
- www.scopus.com
Cancers Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 11
Citações Recebidas na Scopus: 18
Documentos
- Não há documentos
Filiações
Keywords
- gastric cancer; family history; international consortium; meta-analyses
Financiamento
Proyectos asociados
Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2020
Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2020
RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2019
Citar a publicação
Vitelli F,Rubín M,Pelucchi C,Benavente Y,Bonzi R,Rota M,Palli D,Ferraroni M,Lunet N,Morais S,Ye WM,Plymoth A,Malekzadeh R,Tsugane S,Hidaka A,Aragonés N,Castaño G,Zaridze DG,Maximovich D,Vioque J,García M,Zhang ZF,Hamada GS,Pakseresht M,Pourfarzi F,Mu LN,Boccia S,Pastorino R,Yu GP,Lagiou A,Lagiou P,Negri E,La Vecchia C,Martín V. Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium. Cancers. 2021. 13. (15):p. 3844-3844. IF:6,575. (1).
