Portal de investigação
Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- van Meel, ER
- Mensink-Bout, SM
- den Dekker, HT
- Ahluwalia, TS
- Annesi-Maesano, I
- Arshad, SH
- Baïz, N
- von Berg, A
- Bisgaard, H
- Bonnelykke, K
- Carlsson, CJ
- Casas, M
- Chatzi, L
- Chevrier, C
- Dalmeijer, G
- Dezateux, C
- Duchen, K
- Eggesbo, M
- van der Ent, C
- Fantini, M
- Flexeder, C
- Frey, U
- Forastiere, F
- Gehring, U
- Gori, D
- Granell, R
- Griffiths, LJ
- Inskip, H
- Jerzynska, J
- Karvonen, AM
- Keil, T
- Kelleher, C
- Kogevinas, M
- Koppen, G
- Kuehni, CE
- Lambrechts, N
- Lau, S
- Lehmann, I
- Ludvigsson, J
- Magnus, MC
- Mélen, E
- Mehegan, J
- Mommers, M
- Andersen, AMN
- Nystad, W
- Pedersen, ESL
- Pekkanen, J
- Peltola, V
- Pike, KC
- de Moira, AP
- Pizzi, C
- Polanska, K
- Popovic, M
- Porta, D
- Roberts, G
- Schultz, ES
- Standl, M
- Sunyer, J
- Thijs, C
- Toivonen, L
- Uphoff, E
- Usemann, J
- Vafeidi, M
- Wright, J
- de Jongste, JC
- Jaddoe, VWV
- Duijts, L
Unidades de investigação
Abstract
Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4-15) years. Results Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: -0.09 (95% CI -0.14- -0.04) to -0.30 (95% CI -0.36- -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98-2.22) to 6.30 (95% CI 5.64-7.04) and 1.25 (95% CI 1.18-1.32) to 1.55 (95% CI 1.47-1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
Dados da publicação
- ISSN/ISSNe:
- 1399-3003, 1399-3003
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
European Respiratory Journal European Respiratory Society
Citações Recebidas na Web of Science: 10
Citações Recebidas na Scopus: 42
Documentos
- Não há documentos
Filiações
Keywords
- WHEEZING RHINOVIRUS ILLNESSES; IMMUNE-RESPONSES; CHILDHOOD; BRONCHIOLITIS; DISEASE; COHORT; PNEUMONIA; ADULTHOOD; VIRUSES; 1ST
Financiamento
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Citar a publicação
van ER,Mensink SM,den HT,Ahluwalia TS,Annesi I,Arshad SH,Baïz N,Barros H,von A,Bisgaard H,Bonnelykke K,Carlsson CJ,Casas M,Chatzi L,Chevrier C,Dalmeijer G,Dezateux C,Duchen K,Eggesbo M,van der Ent C,Fantini M,Flexeder C,Frey U,Forastiere F,Gehring U,Gori D,Granell R,Griffiths LJ,Inskip H,Jerzynska J,Karvonen AM,Keil T,Kelleher C,Kogevinas M,Koppen G,Kuehni CE,Lambrechts N,Lau S,Lehmann I,Ludvigsson J,Magnus MC,Mélen E,Mehegan J,Mommers M,Andersen A,Nystad W,Pedersen E,Pekkanen J,Peltola V,Pike KC,de Moira AP,Pizzi C,Polanska K,Popovic M,Porta D,Roberts G,Santos AC,Schultz ES,Standl M,Sunyer J,Thijs C,Toivonen L,Uphoff E,Usemann J,Vafeidi M,Wright J,de Jongste JC,Jaddoe VWV,Duijts L. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children. Eur. Respir. J. 2022. 60. (4):2102395. IF:24,300. (1).
