The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity

Autores da FMUP

• Marta Borges Canha

  Autor

• João Sérgio De Lima Soares Neves

  Autor

• Fernando Miguel Da Silva Mendonça

  Autor

• Vanessa Alexandra Guerreiro Gonçalves

  Autor

• Madalena Pereira De Sousa Von Hafe Pérez

  Autor

• Catarina Afonso Couto E Vale

  Autor

• Eva Lau Gouveia

  Autor

• Paula Isabel Marques Simões De Freitas

  Autor

• Davide Maurício Costa Carvalho

  Autor

Participantes de fora da FMUP

• Silva, MM
• Costa, C
• Cabral, PM
• Lourenço, R
• Meira, P
• Salazar, D
• Ferreira, MJ
• Pedro, J
• Leite, AR
• Viana, S
• Sande, A
• Belo, S

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. Patients with missing vitamin D levels or hepatic profile parameters were excluded. We divided the population according to two cut-offs of vitamin D levels (12ng/mL and 20ng/mL). Results: The included population (n=1124) had an average age of 43.3 +/- 10.7 years and 84.3% were female. Seventy-point eight percent of the population had vitamin D levels lower than 2Ong/mL and 34.8% lower than 12ng/dL. Patients with lower vitamin D levels (<12ng/mL) had higher BMI, hip and waist circumferences and higher prevalence of hypertension. Higher FLI scores [OR= 0.77 (0.07), p<0.011 and ALP levels [beta= -0.03 (-0.06, -0.01), p<0.011 associated to lower vitamin D levels. Conclusion: Vitamin D deficiency is associated with a higher risk of hepatic steatosis in individuals with morbid obesity. Conclusion of vitamin D deficiency may have a beneficial role in the management of NAFLD in patients with morbid obesity.

Keywords

• vitamin D; fatty liver; NAFLD; obesity