Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Pooling Project (StoP)

Data de publicação:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Vitelli-Storelli, F
  • Rossi, M
  • Pelucchi, C
  • Rota, M
  • Palli, D
  • Ferraroni, M
  • Morais, S
  • López-Carrillo, L
  • Zaridze, DG
  • Maximovich, D
  • García, MR
  • Castaño-Vinyals, G
  • Aragonés, N
  • de la Hera, MG
  • Hernández-Ramírez, RU
  • Negri, E
  • Bonzi, R
  • Ward, MH
  • Lagiou, A
  • Lagiou, P
  • López-Cervantes, M
  • Boffetta, P
  • Camargo, MC
  • Curado, MP
  • Zhang, ZF
  • Vioque, J
  • La Vecchia, C
  • Sánchez, VM

Unidades de investigação

Abstract

Simple Summary Gastric cancer (GC) has the fifth highest incidence of any cancer type worldwide and the third highest mortality rate, so its prevention is very important. Among dietary factors, the consumption of fruit and vegetables has been inversely related to GC risk. Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer. However, selected polyphenol classes have not been adequately investigated in relation to GC. There is, however, no comprehensive analysis of polyphenols and GC risk methods to date. In order to provide a detailed evaluation of the relationship between dietary intake of polyphenols and GC risk, we analyzed data from the Stomach cancer Pooling (StoP) Project consortium. Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54-0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55-0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56-0.92), flavanols (OR = 0.77, 95% CI = 0.66-0.88), flavanones (OR = 0.57, 95%CI = 0.44-0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55-0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57-0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51-1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58-1.06). Further investigations from longitudinal data are needed to confirm this association.

Dados da publicação

ISSN/ISSNe:
2072-6694, 2072-6694

Cancers  Multidisciplinary Digital Publishing Institute (MDPI)

Tipo:
Article
Páginas:
1-12
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 8

Citações Recebidas na Scopus: 17

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Keywords

  • diet; epidemiology; flavonoids; gastric cancer; polyphenols

Financiamento

Proyectos asociados

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Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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