Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Data de publicação:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Martimianaki, G
  • Bertuccio, P
  • Alicandro, G
  • Pelucchi, C
  • Bravi, F
  • Carioli, G
  • Bonzi, R
  • Rabkin, CS
  • Liao, LM
  • Sinha, R
  • Johnson, K
  • Hu, JF
  • Palli, D
  • Ferraroni, M
  • Morais, S
  • Tsugane, S
  • Hidaka, A
  • Hamada, GS
  • López-Carrillo, L
  • Hernández-Ramírez, RU
  • Zaridze, D
  • Maximovitch, D
  • Aragonés, N
  • Martin, V
  • Ward, MH
  • Vioque, J
  • de la Hera, MG
  • Zhang, ZF
  • Kurtz, RC
  • Lagiou, P
  • Lagiou, A
  • Trichopoulou, A
  • Karakatsani, A
  • Malekzadeh, R
  • Camargo, MC
  • Curado, MP
  • Boccia, S
  • Boffetta, P
  • Negri, E
  • La Vecchia, C

Unidades de investigação

Abstract

Objective This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. Methods A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. Results Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. Conclusions These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

Dados da publicação

ISSN/ISSNe:
1473-5709, 0959-8278

EUROPEAN JOURNAL OF CANCER PREVENTION  Lippincott Williams and Wilkins Ltd.

Tipo:
Article
Páginas:
117-127
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 7

Citações Recebidas na Scopus: 15

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Keywords

  • cardia cancer; case-control study; coffee; gastric cancer; pooled analysis

Financiamento

Proyectos asociados

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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