Portal de investigação
Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Dalmartello, M
- Turati, F
- Zhang, ZF
- Rota, M
- Bonzi, R
- Galeone, C
- Martimianaki, G
- Palli, D
- Ferraroni, M
- Yu, GP
- Morais, S
- Malekzadeh, R
- López-Carrillo, L
- Zaridze, D
- Maximovitch, D
- Aragonés, N
- Fernández-Tardón, G
- Martin, V
- Vioque, J
- de la Hera, MG
- Curado, MP
- Coimbra, FJF
- Assumpcao, P
- Pakseresht, M
- Hu, JF
- Hernández-Ramírez, RU
- Ward, MH
- Pourfarzi, F
- Mu, LN
- Tsugane, S
- Hidaka, A
- Lagiou, P
- Lagiou, A
- Trichopoulou, A
- Karakatsani, A
- Boffetta, P
- Camargo, MC
- Negri, E
- La Vecchia, C
- Pelucchi, C
Unidades de investigação
Abstract
Background The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I-2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. Conclusions In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
Dados da publicação
- ISSN/ISSNe:
- 1532-1827, 0007-0920
- Tipo:
- Article
- Páginas:
- 1755-1764
- Link para outro recurso:
- www.scopus.com
British Journal of Cancer Nature Publishing Group
Citações Recebidas na Web of Science: 7
Citações Recebidas na Scopus: 10
Documentos
- Não há documentos
Filiações
Keywords
- HELICOBACTER-PYLORI; MEDITERRANEAN DIET; ALCOHOL-CONSUMPTION; POOLED ANALYSES; ADENOCARCINOMA; METAANALYSIS; FRUIT; VITAMIN; LANDSCAPE; ADHERENCE
Financiamento
Proyectos asociados
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Citar a publicação
Dalmartello M,Turati F,Zhang ZF,Lunet N,Rota M,Bonzi R,Galeone C,Martimianaki G,Palli D,Ferraroni M,Yu GP,Morais S,Malekzadeh R,López L,Zaridze D,Maximovitch D,Aragonés N,Fernández G,Martin V,Vioque J,de la Hera MG,Curado MP,Coimbra FJF,Assumpcao P,Pakseresht M,Hu JF,Hernández RU,Ward MH,Pourfarzi F,Mu LN,Tsugane S,Hidaka A,Lagiou P,Lagiou A,Trichopoulou A,Karakatsani A,Boffetta P,Camargo MC,Negri E,La Vecchia C,Pelucchi C. Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project. Br. J. Cancer. 2022. 126. (12):p. 1755-1764. IF:8,800. (1).
