Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Dalmartello, M
  • Turati, F
  • Zhang, ZF
  • Rota, M
  • Bonzi, R
  • Galeone, C
  • Martimianaki, G
  • Palli, D
  • Ferraroni, M
  • Yu, GP
  • Morais, S
  • Malekzadeh, R
  • López-Carrillo, L
  • Zaridze, D
  • Maximovitch, D
  • Aragonés, N
  • Fernández-Tardón, G
  • Martin, V
  • Vioque, J
  • de la Hera, MG
  • Curado, MP
  • Coimbra, FJF
  • Assumpcao, P
  • Pakseresht, M
  • Hu, JF
  • Hernández-Ramírez, RU
  • Ward, MH
  • Pourfarzi, F
  • Mu, LN
  • Tsugane, S
  • Hidaka, A
  • Lagiou, P
  • Lagiou, A
  • Trichopoulou, A
  • Karakatsani, A
  • Boffetta, P
  • Camargo, MC
  • Negri, E
  • La Vecchia, C
  • Pelucchi, C

Unidades de investigação

Abstract

Background The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I-2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. Conclusions In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.

Dados da publicação

ISSN/ISSNe:
1532-1827, 0007-0920

British Journal of Cancer  Nature Publishing Group

Tipo:
Article
Páginas:
1755-1764
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 7

Citações Recebidas na Scopus: 10

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Keywords

  • HELICOBACTER-PYLORI; MEDITERRANEAN DIET; ALCOHOL-CONSUMPTION; POOLED ANALYSES; ADENOCARCINOMA; METAANALYSIS; FRUIT; VITAMIN; LANDSCAPE; ADHERENCE

Financiamento

Proyectos asociados

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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