Psychological profiles of patients with suspected drug allergy

Data de publicação:

Autores da FMUP

  • Laura Virginia Pereira Teixeira Ribeiro

    Autor

Participantes de fora da FMUP

  • de Castro, ED
  • Leblanc, A
  • Barbosa, J.
  • Cernadas, JR

Unidades de investigação

Abstract

Background: Several studies demonstrate an important association between allergic diseases and patients' psychological characteristics. Objective: To evaluate any differences in the psychological characteristics of patients studied for suspected drug allergy in comparison with healthy controls. A secondary aim was to assess differences between patients with confirmed versus excluded drug allergy, with respect to the clinical aspects. Methods: The psychological characteristics of 115 consecutive patients >16 years-old, studied for suspected drug allergy were assessed. They were compared with healthy controls. Four validated questionnaires were used to evaluate anxiety, depression, alexithymia, and personality type. Results: Eighty-eight patients completed the evaluation: 34 had confirmed drug allergy and 33 excluded. Forty-eight healthy subjects filled the 4 questionnaires. Increased neuroticism was associated with increased odds of belonging to the excluded drug allergy group (odds ratio [OR], 1.374; 95% confidence interval [CI], 1.173-1.609). Increased neuroticism (OR, 1.244; 95% CI, 1.065-1.453) and increased anxiety (OR, 1.210; 95% CI, 1.084-1.351) were associated with increased odds of confirmed drug allergy. However, higher extraversion decreased this likelihood (OR, 0.755; 95% CI, 0.643-0.888). The odds of having confirmed drug allergy was reduced by 79.7% (OR, 0.203; 95% CI, 0.060-0.694) for patients with 2 suspected drugs and by 84.6% (OR, 0.154; 95% CI, 0.029-0.809) for those with >= 3 in comparison to those with only one. Patients with moderate to severe reactions were more likely to have confirmed drug allergy (OR, 4.295; 95% CI, 1.105-16.693) than those with milder manifestations. Conclusion: Our results highlight that patients with drug allergy have a distinctive psychological profile. Psychological assessment may help to identify patients that would benefit from a targeted intervention.

Dados da publicação

ISSN/ISSNe:
2233-8268, 2233-8276

Asia Pacific Allergy  Asia Pacific Association of Allergy, Asthma and Clinical Immunology

Tipo:
Article
Páginas:
-

Citações Recebidas na Web of Science: 4

Documentos

  • Não há documentos

Métricas

Filiações mostrar / ocultar

Keywords

  • Drug allergy; Psychological assessment; Anxiety; Depression; Alexithymia; Personality type

Proyectos asociados

Ensino-aprendizagem e perfil psicológico dos estudantes de medicina na pandemia Covid-19.

Investigador Principal: Laura Virginia Pereira Teixeira Ribeiro

Estudo Observacional Académico (PerfilPsic) . 2020

Catecholaminergic system regulation in adipose tissue under obesity

Investigador Principal: Laura Virginia Pereira Teixeira Ribeiro

Estudo Clínico Académico . 2020

Citar a publicação

Partilhar a publicação