Psychological profiles of patients with suspected drug allergy

Autores da FMUP
Participantes de fora da FMUP
- de Castro, ED
- Leblanc, A
- Barbosa, J.
- Cernadas, JR
Unidades de investigação
Abstract
Background: Several studies demonstrate an important association between allergic diseases and patients' psychological characteristics. Objective: To evaluate any differences in the psychological characteristics of patients studied for suspected drug allergy in comparison with healthy controls. A secondary aim was to assess differences between patients with confirmed versus excluded drug allergy, with respect to the clinical aspects. Methods: The psychological characteristics of 115 consecutive patients >16 years-old, studied for suspected drug allergy were assessed. They were compared with healthy controls. Four validated questionnaires were used to evaluate anxiety, depression, alexithymia, and personality type. Results: Eighty-eight patients completed the evaluation: 34 had confirmed drug allergy and 33 excluded. Forty-eight healthy subjects filled the 4 questionnaires. Increased neuroticism was associated with increased odds of belonging to the excluded drug allergy group (odds ratio [OR], 1.374; 95% confidence interval [CI], 1.173-1.609). Increased neuroticism (OR, 1.244; 95% CI, 1.065-1.453) and increased anxiety (OR, 1.210; 95% CI, 1.084-1.351) were associated with increased odds of confirmed drug allergy. However, higher extraversion decreased this likelihood (OR, 0.755; 95% CI, 0.643-0.888). The odds of having confirmed drug allergy was reduced by 79.7% (OR, 0.203; 95% CI, 0.060-0.694) for patients with 2 suspected drugs and by 84.6% (OR, 0.154; 95% CI, 0.029-0.809) for those with >= 3 in comparison to those with only one. Patients with moderate to severe reactions were more likely to have confirmed drug allergy (OR, 4.295; 95% CI, 1.105-16.693) than those with milder manifestations. Conclusion: Our results highlight that patients with drug allergy have a distinctive psychological profile. Psychological assessment may help to identify patients that would benefit from a targeted intervention.
Dados da publicação
- ISSN/ISSNe:
- 2233-8268, 2233-8276
- Tipo:
- Article
- Páginas:
- -
Asia Pacific Allergy Asia Pacific Association of Allergy, Asthma and Clinical Immunology
Citações Recebidas na Web of Science: 4
Documentos
- Não há documentos
Filiações
Keywords
- Drug allergy; Psychological assessment; Anxiety; Depression; Alexithymia; Personality type
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Citar a publicação
de Castro ED,Leblanc A,Barbosa J,Ribeiro L,Cernadas JR. Psychological profiles of patients with suspected drug allergy. Asia Pac. Allergy. 2020. 10. (4):e39.