Portal de investigação
Mechanisms of Acquired In Vivo and In Vitro Resistance to Voriconazole by Candida krusei following Exposure to Suboptimal Drug Concentration
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Grenouillet, F
- Silva, RM
- Eglin, G
- Devillard, N
Unidades de investigação
Abstract
Five Candida krusei isolates (susceptible and resistant) recovered from the urine of a kidney transplant patient treated with voriconazole (VRC) 200 mg twice daily for 20 days were studied. Eight unrelated clinical isolates of C. krusei were exposed in vitro to VRC 0.001 mu g/ml for 30 days. Development of VRC transient resistance occurred in vivo, and induction of permanent resistance occurred in vitro. Mostly, ABC1 and ERG11 genes were overexpressed, and a homozygous T418C mutation in the ERG11 gene was found.
Dados da publicação
- ISSN/ISSNe:
- 1098-6596, 0066-4804
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1128/AAC.01651-19
- Link para outro recurso:
- www.scopus.com
Antimicrobial Agents and Chemotherapy American Society for Microbiology
Citações Recebidas na Web of Science: 5
Citações Recebidas na Scopus: 8
Documentos
- Não há documentos
Filiações
Keywords
- Candida krusei; underexposure to antifungal drugs; mechanisms of antifungal resistance; ABC1 ABC2 efflux pump genes; ERG11 gene mutations; candiduria; voriconazole; candidiasis
Financiamento
Proyectos asociados
Emergence of multidrug cross-resistance between agricultural and human antifungals in clinically relevant species of Aspergillus and Candida
Investigador Principal: Acácio Agostinho Gonçalves Rodrigues
Estudo Clínico Académico . 2019
Citar a publicação
Ricardo E,Grenouillet F,Miranda I,Silva RM,Eglin G,Devillard N,Rodrigues A,Pina C. Mechanisms of Acquired <i>In Vivo</i> and <i>In Vitro</i> Resistance to Voriconazole by <i>Candida krusei</i> following Exposure to Suboptimal Drug Concentration. Antimicrob. Agents Chemother. 2020. 64. (4):e01651-19. IF:5,191. (1).
