Portal de investigação
Blood, Gut, and Oral Microbiome in Kidney Transplant Recipients
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Sampaio, S
- Araujo, R
- Merino-Riba, A
- Lelouvier, B
- Servant, F
- Sampaio Maia, B.
Unidades de investigação
Abstract
Background and Objective:Recent reports describe the existence of a blood microbiome profile not associated with an infection state. Given the high impact that the dysbiotic human microbiome appears to have in chronic kidney disease and, in particular, in the outcome of kidney transplant recipients (KTRs), we aimed to explore the variations and correlations of the gut, oral, and blood microbiome of recipients, 3 months after kidney transplantation. Materials and Methods:We conducted a cross-sectional study where the microbiome of stool, saliva, and blood collected from recipients 3 months after kidney transplantation (N = 6) was analyzed by polymerase chain reaction (PCR) amplification and sequencing of the V3-V4 hypervariable regions of the 16S rRNA gene using MiSeq Illumina (R) technology. Results:Blood of KTRs harbors a distinct low-abundance microbiome dominated by Proteobacteria and Firmicutes. Gut and oral microbiome of KTRs also present distinct profiles. The existence of a proportion of shared operational taxonomic units among the different body sites is reported, mainly classified as Proteobacteria and Firmicutes. Conclusions:This study provides evidence of existence a blood microbiome in KTRs, different from the gut and the oral microbiome profiles, with a small number of operational taxonomic units representing a shared microbiome. The clinical relevance of this observation should be further explored in these patients.
Copyright: © 2023 Indian Journal of Nephrology.
Dados da publicação
- ISSN/ISSNe:
- 0971-4065, 1998-3662
- Tipo:
- Article
- Páginas:
- 366-370
- Link para outro recurso:
- www.scopus.com
Indian Journal of Nephrology Wolters Kluwer Medknow Publications
Citações Recebidas na Scopus: 3
Documentos
- Não há documentos
Filiações
Keywords
- Bloodstream; human microbiome; kidney transplantation; kidney transplant recipients; mobile bacteria
Financiamento
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Citar a publicação
Sampaio S,Araujo R,Merino A,Lelouvier B,Servant F,Quelhas J,Pestana M,Sampaio B. Blood, Gut, and Oral Microbiome in Kidney Transplant Recipients. Indian J Nephrol. 2023. 33. (5):p. 366-370.
