Use of sodium glucose co-transporter 2 inhibitors in acute heart failure: a practical guidance

Autores da FMUP

• João Pedro Melo Marques Pinho Ferreira

  Autor

• Joana Lídia Martins Pimenta

  Autor

• Brenda Eugénia Carvalho De Moura Cardoso

  Autor

Participantes de fora da FMUP

• Aguiar, C
• Franco, F

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Aims Heart failure (HF) is the most frequent cause of hospital admission among patients 65 years or older. Patients hospitalized for acutely decompensated chronic HF and 'de novo' acute heart failure (AHF) continue to experience unacceptably high post-discharge readmission and mortality rates. Methods and results Until recently, trials had failed to improve outcome in patients with AHF irrespective of ejection fraction with exception of sodium-glucose co-transporter 2 inhibitors (SGLT2i) that improved clinical outcomes in patients hospitalized for AHF in the Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure (EMPULSE) and in the Effect of Sotagliflozin on Cardiovascular Events in Patients With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF) trials. Conclusions This document reviews the potential utility of SGLT2i in patients hospitalized for AHF.

Keywords

• Sodium-glucose co-transporter 2 inhibitors; Acute heart failure; Outcomes