Portal de investigação
Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Santos, E
- Moura, J
- Samoes, R
- Sousa, AP
- Mendonça, T
- Correia, I
- Duraes, J
- Sousa, L
- de Sá, J
- Sousa, F
- Sequeira, M
- Correia, AS
- André, AL
- Basílio, C
- Arenga, M
- Marques, IB
- Perdigao, S
- Alves, I
- Santos, M
- Salgado, V
- Palos, A
- Guerreiro, R
- Isidoro, L
- Boleixa, D
- Carneiro, P
- Neves, E
- Silva, AM
- Gonçalves, G
- Sá, MJ
Unidades de investigação
Abstract
Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMOSD study we analyzed the clinical/demographic characteristics of the LONMOSD. Results: From the 180 Portuguese patients 45 had disease onset after 50 years old, 80% were female. 23 had anti-AQP4 antibodies (51.1%), 13 anti-MOG antibodies (28.9%) and 9 were double seronegative (20.0%). The most common presenting phenotypes in LONMOSD were transverse myelitis (53.3%) and optic neuritis (26.7%), without difference from EONMOSD (p = 0.074). The mean EDSS for LONMOSD was 6.0 (SD=2.8), after a mean follow-up time of 4.58 (SD=4.47) years, which was significantly greater than the mean EDSS of EONMOSD (3.25, SD=1.80)(p = 0.022). Anti-AQP4 antibodies positive LONMOSD patients had increased disability compared to anti-MOG antibodies positive LONMOSD (p = 0.022). The survival analysis showed a reduced time to use a cane for LONMOSD, irrespective of serostatus (p<0.001). Conclusions: LONMOSD has increased disability and faster progression, despite no differences in the presenting clinical phenotype were seen in our cohort.
Dados da publicação
- ISSN/ISSNe:
- 2211-0356, 2211-0348
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Multiple Sclerosis and Related Disorders Elsevier
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 7
Documentos
- Não há documentos
Filiações
Keywords
- Aquaporin 4; Autoantibodies; Female; Humans; Male; Myelitis, Transverse; Neuromyelitis Optica; Portugal; aquaporin 4 antibody; azathioprine; immunoglobulin; methotrexate; mycophenolate mofetil; myelin oligodendrocyte glycoprotein antibody; protein antibody; rituximab; steroid; unclassified drug; aquaporin 4; autoantibody; adult; aged; Article; clinical feature; cohort analysis; controlled study; demographics; disability; disease exacerbation; female; follow up; human; major clinical study; male; middle aged; myelooptic neuropathy; optic neuritis; phenotype; plasma exchange; Portuguese (citizen); retrospective study; survival analysis; transverse myelitis; very elderly; myelitis; myelooptic neuropathy; Portugal
Financiamento
Proyectos asociados
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Optical Coherence Tomography in Multiple Sclerosis patients regarding history of Optic Neuritis: a Portuguese hospital-based study
Investigador Principal: Joana da Cruz Guimarães Ferreira de Almeida
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Citar a publicação
Santos E,Moura J,Samoes R,Sousa AP,Mendonça T,Abreu P,Guimaraes J,Correia I,Duraes J,Sousa L,Ferreira J,de Sá J,Sousa F,Sequeira M,Correia AS,André AL,Basílio C,Arenga M,Marques IB,Perdigao S,Alves I,Santos M,Salgado V,Palos A,Guerreiro R,Isidoro L,Boleixa D,Carneiro P,Neves E,Silva AM,Gonçalves G,Sá MJ. Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups. Mult. Scler. Relat. Disord. 2022. 63. 103845. IF:4,000. (2).
