Portal de investigação
Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Santos, E
- Moura, J
- Samoes, R
- Sousa, AP
- Mendonça, T
- Correia, I
- Duraes, J
- Sousa, L
- de Sá, J
- Sousa, F
- Sequeira, M
- Correia, AS
- André, AL
- Basílio, C
- Arenga, M
- Marques, IB
- Perdigao, S
- Alves, I
- Santos, M
- Salgado, V
- Palos, A
- Guerreiro, R
- Isidoro, L
- Boleixa, D
- Carneiro, P
- Neves, E
- Silva, AM
- Gonçalves, G
- Sá, MJ
Unidades de investigação
Abstract
Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMOSD study we analyzed the clinical/demographic characteristics of the LONMOSD. Results: From the 180 Portuguese patients 45 had disease onset after 50 years old, 80% were female. 23 had anti-AQP4 antibodies (51.1%), 13 anti-MOG antibodies (28.9%) and 9 were double seronegative (20.0%). The most common presenting phenotypes in LONMOSD were transverse myelitis (53.3%) and optic neuritis (26.7%), without difference from EONMOSD (p = 0.074). The mean EDSS for LONMOSD was 6.0 (SD=2.8), after a mean follow-up time of 4.58 (SD=4.47) years, which was significantly greater than the mean EDSS of EONMOSD (3.25, SD=1.80)(p = 0.022). Anti-AQP4 antibodies positive LONMOSD patients had increased disability compared to anti-MOG antibodies positive LONMOSD (p = 0.022). The survival analysis showed a reduced time to use a cane for LONMOSD, irrespective of serostatus (p<0.001). Conclusions: LONMOSD has increased disability and faster progression, despite no differences in the presenting clinical phenotype were seen in our cohort.
Dados da publicação
- ISSN/ISSNe:
- 2211-0356, 2211-0348
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 35594635
- Link para outro recurso:
- www.scopus.com
Multiple Sclerosis and Related Disorders Elsevier
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 7
Documentos
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Filiações
Keywords
- Aquaporin 4; Autoantibodies; Female; Humans; Male; Myelitis, Transverse; Neuromyelitis Optica; Portugal; aquaporin 4 antibody; azathioprine; immunoglobulin; methotrexate; mycophenolate mofetil; myelin oligodendrocyte glycoprotein antibody; protein antibody; rituximab; steroid; unclassified drug; aquaporin 4; autoantibody; adult; aged; Article; clinical feature; cohort analysis; controlled study; demographics; disability; disease exacerbation; female; follow up; human; major clinical study; male; middle aged; myelooptic neuropathy; optic neuritis; phenotype; plasma exchange; Portuguese (citizen); retrospective study; survival analysis; transverse myelitis; very elderly; myelitis; myelooptic neuropathy; Portugal
Financiamento
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