Could Bone Biomarkers Predict Bone Turnover after Kidney Transplantation?-A Proof-of-Concept Study

Data de publicação:

Autores da FMUP

  • Janete Maria Quelhas Dos Santos

    Autor

  • Ricardo Morais Pereira Neto

    Autor

  • João Miguel Machado Dória Frazão

    Autor

Participantes de fora da FMUP

  • Magalhaes, J
  • Pereira, L
  • Castro Ferreira, I
  • Martins, S
  • Carvalho, C

Unidades de investigação

Abstract

Aim: Bone disease after kidney transplant (KT) results from multiple factors, including previous bone and mineral metabolism disturbances and effects of transplant-related medications. New biomolecules have been recently associated with the development and progression of the chronic kidney disease-associated bone and mineral disorder (CKD-MBD). These include sclerostin and the soluble receptor activator of nuclear factor-kB ligand (sRANKL). Methods: To better understand the role of biomarkers in post-transplant bone disease, this study was designed to prospectively evaluate and correlate results from the histomorphometric analysis of bone biopsies after KT with emerging serum biomarkers of the CKD-MBD: sclerostin, Dickkopf-related protein 1 (Dkk-1), sRANKL and osteo-protegerin (OPG). Results: Our data shows a significant increase in plasma levels of bioactive sclerostin after KT accompanied by a significant reduction in plasma levels of Dkk-1, suggesting a promotion of the inhibition of bone formation by osteoblasts through the activation of these inhibitors of the Wnt signaling pathway. In addition, we found a significant increase in plasma levels of free sRANKL after KT accompanied by a significant reduction in plasma levels of its decoy receptor OPG, suggesting an enhanced bone resorption by osteoclasts mediated by this mechanism. Conclusions: Taken together, these results suggest that the loss of bone volume observed after KT could be explain mainly by the inhibition of bone formation mediated by sclerostin accompanied by an enhanced bone resorption mediated by sRANKL.

Dados da publicação

ISSN/ISSNe:
2077-0383, 2077-0383

Journal of Clinical Medicine  MDPI AG

Tipo:
Article
Páginas:
457-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 3

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Keywords

  • bone biomarkers; kidney transplantation; bone turnover

Proyectos asociados

Update on the impact of sodium-glucose cotransporter inhibitors in diabetic kidney disease progression

Investigador Principal: Ricardo Morais Pereira Neto

Estudo Clínico Académico (Diabetic Kidney) . 2020

Novos Agentes Redutores de Potássio na Abordagem da Hipercalémia na Doença Renal Crónica

Investigador Principal: Ricardo Morais Pereira Neto

Estudo Clínico Académico . 2021

Kidney-induced osteoporosis: a new entity with a novel therapeutic approach.

Investigador Principal: João Miguel Machado Dória Frazão

Estudo Clínico Académico . 2020

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