Low bone turnover is associated with plain X-ray vascular calcification in predialysis patients

Data de publicação:

Autores da FMUP

  • Ricardo Morais Pereira Neto

    Autor

  • Janete Maria Quelhas Dos Santos

    Autor

  • João Miguel Machado Dória Frazão

    Autor

Participantes de fora da FMUP

  • Pereira, L
  • Magalhaes, J

Unidades de investigação

Abstract

Background Vascular calcification (VC) is a common finding in chronic kidney disease (CKD) patients and predicts subsequent cardiovascular morbidity and mortality in this population. Vascular calcification is linked to disordered mineral metabolism and has been associated with bone histomorphometry changes in CKD. However, data on predialysis patients is scarce. Methods A cross-sectional study was conducted on a cohort of 56 CKD patients not yet on dialysis, who underwent a transiliac bone biopsy for histomorphometric evaluation after double tetracycline labeling. Patients had no previous exposure to calcium salts, vitamin D agents, steroids or bisphosphonates. Vascular calcification was assessed at the time of biopsy, using Kauppila (plain X-ray of the lateral lumbar spine) and AdragAo (plain X-ray of the pelvis and hands) scores. Results Vascular calcification was seen in two-thirds of the cohort. Subjects with VC were more likely to be male and have diabetes, and had significantly higher sclerostin and osteoprotegerin circulating levels than those without VC. The histomorphometric analysis showed that bone formation rate was significantly lower in VC compared to non-VC patients. In the multivariable logistic regression analysis, bone formation rate was independently associated with the presence of VC. Conclusions Vascular calcification is highly prevalent in predialysis patients, especially in those with diabetes. The independent association between bone formation rate and VC provides evidence of an important interaction between bone and vessel in CKD. Our results suggest that low bone turnover is a non-traditional risk factor for cardiovascular disease in predialysis patients.

Dados da publicação

ISSN/ISSNe:
1932-6203, 1932-6203

PLoS ONE  Public Library of Science

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 6

Citações Recebidas na Scopus: 8

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Keywords

  • Aged; Bone and Bones; Bone Remodeling; Female; Humans; Male; Middle Aged; Multivariate Analysis; Regression Analysis; Renal Dialysis; Renal Insufficiency, Chronic; Vascular Calcification; X-Rays; doxycycline; osteoprotegerin; sclerostin; adult; aged; Article; blood vessel calcification; bone biopsy; bone turnover; cardiovascular disease; cardiovascular risk; chronic kidney failure; cohort analysis; cross-sectional study; diabetes mellitus; drug labeling; female; hand radiography; hemodialysis; human; lumbar spine; major clinical study; male; middle aged; morphometry; observational study; ossification; pelvis radiography; prevalence; sex difference; spine radiography; blood vessel calcification; bone; bone remodeling; chronic kidney failure; complication; diagnostic imaging; multivariate analysis; pathology; pathophysiology; physiology; regression analysis; X ray

Proyectos asociados

Update on the impact of sodium-glucose cotransporter inhibitors in diabetic kidney disease progression

Investigador Principal: Ricardo Morais Pereira Neto

Estudo Clínico Académico (Diabetic Kidney) . 2020

Novos Agentes Redutores de Potássio na Abordagem da Hipercalémia na Doença Renal Crónica

Investigador Principal: Ricardo Morais Pereira Neto

Estudo Clínico Académico . 2021

Kidney-induced osteoporosis: a new entity with a novel therapeutic approach.

Investigador Principal: João Miguel Machado Dória Frazão

Estudo Clínico Académico . 2020

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