Portal de investigação
Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epidemiological study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Santos, E
- Rocha, AL
- Oliveira, V
- Ferro, D
- Samo, R
- Sousa, AP
- Figueiroa, S
- Mendonça, T
- Sousa, R
- Correia, I
- Duraes, J
- Sousa, L
- de Sá, J
- Sousa, F
- Sequeira, M
- Correia, AS
- André, AL
- Basilio, C
- Arenga, M
- Mendes, I
- Marques, IB
- Perdigao, S
- Felgueiras, H
- Alves, I
- Correia, F
- Barroso, C
- Morganho, A
- Carmona, C
- Palavra, F
- Santos, M
- Salgado, V
- Palos, A
- Nzwalo, H
- Timóteo, A
- Guerreiro, R
- Isidoro, L
- Boleixa, D
- Carneiro, P
- Neves, E
- Silva, AM
- Gonçalves, G
- Leite, MI
- Sá, MJ
Unidades de investigação
Abstract
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients were included. Results: A total of 180 patients met the 2015 Wingerchuk NMOSD criteria, 77 were AQP4-antibody positive (Abs+), 67 MOG-Abs+, and 36 seronegative. Point prevalence on December 31, 2018 was 1.71/100,000 for NMOSD, 0.71/100,000 for AQP4-Abs+, 0.65/100,000 for MOG-Abs+, and 0.35/100,000 for seronegative NMOSD. A total of 44 new NMOSD cases were identified during the two-year study period (11 AQP4-Abs+, 27 MOG-Abs+, and 6 seronegative). The annual incidence rate in that period was 0.21/100,000 person-years for NMOSD, 0.05/100,000 for AQP4-Abs+, 0.13/100,000 for MOG-Abs+, and 0.03/100,000 for seronegative NMOSD. AQP4-Abs+ predominated in females and was associated with autoimmune disorders. Frequently presented with myelitis. Area postrema syndrome was exclusive of this subtype, and associated with higher morbidity/mortality than other forms of NMOSD. MOG-Ab+ more often presented with optic neuritis, required less immunosuppression, and had better outcome. Conclusion: Epidemiological/clinical NMOSD profiles in the Portuguese population are similar to other European countries
Dados da publicação
- ISSN/ISSNe:
- 2211-0356, 2211-0348
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Multiple Sclerosis and Related Disorders Elsevier
Citações Recebidas na Web of Science: 6
Citações Recebidas na Scopus: 13
Documentos
- Não há documentos
Filiações
Keywords
- Clinical; Epidemiological; Neuromyelitis optica spectrum disorders; Portugal
Campos de estudo
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Citar a publicação
Santos E,Rocha AL,Oliveira V,Ferro D,Samo R,Sousa AP,Figueiroa S,Mendonça T,Abreu P,Guimaraes J,Sousa R,Melo C,Correia I,Duraes J,Sousa L,Ferreira J,de Sá J,Sousa F,Sequeira M,Correia AS,André AL,Basilio C,Arenga M,Mendes I,Marques IB,Perdigao S,Felgueiras H,Alves I,Correia F,Barroso C,Morganho A,Carmona C,Palavra F,Santos M,Salgado V,Palos A,Nzwalo H,Timóteo A,Guerreiro R,Isidoro L,Boleixa D,Carneiro P,Neves E,Silva AM,Gonçalves G,Leite MI,Sá MJ. Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epidemiological study. Mult. Scler. Relat. Disord. 2021. 56. 103258. IF:4,808. (2).
