Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy
Autores da FMUP
Participantes de fora da FMUP
- Portela, F
- Ministro, P
- de Deus, J
- Cravo, M
- Cotter, J
- Duque, G
- Ferreira, F
- Rosa, B
- Ferreira, PL
- Portuguese IBD Study Grp GEDII
Unidades de investigação
Abstract
Purpose:Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients' health-related quality of life (HRQoL).Methods:This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey.Results:We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms - lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (-4.646, 95% CI -6.953 to -2.339) and in the physical functioning (-9.622, 95% CI -17.061 to -2.183) and physical role functioning (-3.669, 95% CI -7.339 to 0.001) dimensions of the SF36.Conclusions:Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs.
Dados da publicação
- ISSN/ISSNe:
- 1421-9867, 0012-2823
- Tipo:
- Article
- Páginas:
- 631-637
- DOI:
- 10.1159/000501823
- Link para outro recurso:
- www.scopus.com
Digestion S. Karger AG
Citações Recebidas na Web of Science: 2
Citações Recebidas na Scopus: 2
Documentos
- Não há documentos
Filiações
Keywords
- Health-related quality of life; Ulcerative colitis; Immunomodulatory; Surgery
Campos de estudo
Financiamento
Proyectos asociados
Contributo da endoscopia, biomarcadores e imagiologia na evolução clinica dos doentes com doença inflamatória intestinal
Investigador Principal: Fernando José Magro Dias
Estudo Clínico Académico . 2019
Citar a publicação
Portela F,Ministro P,de Deus J,Cravo M,Cotter J,Duque G,Ferreira F,Rosa B,Ferreira PL,Dias CC,Magro F,Portuguese IBD Study GEDII GRP. Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy. Digestion. 2020. 101. (5):p. 631-637. IF:3,216. (3).