Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy

Data de publicação:

Autores da FMUP

  • Claudia Camila Rodrigues Pereira Dias

    Autor

  • Fernando José Magro Dias

    Autor

Participantes de fora da FMUP

  • Portela, F
  • Ministro, P
  • de Deus, J
  • Cravo, M
  • Cotter, J
  • Duque, G
  • Ferreira, F
  • Rosa, B
  • Ferreira, PL
  • Portuguese IBD Study Grp GEDII

Unidades de investigação

Abstract

Purpose:Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients' health-related quality of life (HRQoL).Methods:This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey.Results:We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms - lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (-4.646, 95% CI -6.953 to -2.339) and in the physical functioning (-9.622, 95% CI -17.061 to -2.183) and physical role functioning (-3.669, 95% CI -7.339 to 0.001) dimensions of the SF36.Conclusions:Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs.

Dados da publicação

ISSN/ISSNe:
1421-9867, 0012-2823

Digestion  S. Karger AG

Tipo:
Article
Páginas:
631-637
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 2

Citações Recebidas na Scopus: 2

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Keywords

  • Health-related quality of life; Ulcerative colitis; Immunomodulatory; Surgery

Financiamento

Proyectos asociados

Contributo da endoscopia, biomarcadores e imagiologia na evolução clinica dos doentes com doença inflamatória intestinal

Investigador Principal: Fernando José Magro Dias

Estudo Clínico Académico . 2019

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