Portal de investigação
Portuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design - A population-based study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Baptista, R
- Canhao, H
- Rodrigues, AM
- Kislaya, I
- Franco, F
- Bernardo, F
- Mendes, L
- Gon?alves, S
- Timóteo, AT
- Andrade, A
- Mourau, B
- Fonseca, C
- Aguiar, C
- Brito, D
- Ferreira, J
- Peres, M
- Sarmento, PM
- Cernadas, R
- Santos, M
- Fernandes, AC
- Martinho, H
- González-Juanatey, JR
- Pereira, LF
- Gil, V
- Marques, CR
- Almeida, M
- Pardal, M
- Barbosa, V
Unidades de investigação
Abstract
Introduction and objectives: Current epidemiological data on heart failure (HF) in Portugal derives from studies conducted two decades ago. The main aim of this study is to determine HF prevalence in the Portuguese population. Using current standards, this manuscript aims to describe the methodology and research protocol applied. Methods: The Portuguese Heart Failure Prevalence Observational Study (PORTHOS) is a large, three-stage, population-based, nationwide, cross-sectional study. Community-dwelling citizens aged 50 years and older will be randomly selected via stratified multistage sampling. Eligible participants will be invited to attend a screening visit at a mobile clinic for HF symptom assess-ment, anthropomorphic assessment, N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing, one-lead electrocardiogram (ECG) and a sociodemographic and health-related quality of life questionnaire (EQ-5D). All subjects with NT-proBNP >= 125 pg/mL or with a prior history of HF will undergo a diagnostic confirmatory assessment at the mobile clinic composed of a 12-lead ECG, comprehensive echocardiography, HF questionnaire (KCCQ) and blood sampling.To validate the screening procedure, a control group will undergo the same diagnostic assess-ment. Echocardiography results will be centrally validated, and HF diagnosis will be established according to the European Society of Cardiology HF guidelines. A random subsample of patients with an equivocal HF with preserved ejection fraction diagnosis based on the application of the Heart Failure Association preserved ejection fraction diagnostic algorithm will be invited to undergo an exercise echocardiography. Conclusions: Through the application of current standards, appropriate methodologies, and a strong research protocol, the PORTHOS study will determine the prevalence of HF in main-land Portugal and enable a comprehensive characterization of HF patients, leading to a better understanding of their clinical profile and health-related quality of life.(c) 2023 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Dados da publicação
- ISSN/ISSNe:
- 0870-2551, 2174-2030
- Tipo:
- Article
- Páginas:
- 985-995
- Link para outro recurso:
- www.scopus.com
Revista Portuguesa de Cardiologia Sociedade Portuguesa De Cardiologia
Documentos
- Não há documentos
Filiações
Keywords
- Heart failure; Prevalence; Quality of life; Portugal; Epidemiology; PORTHOS
Financiamento
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Citar a publicação
Baptista R,Cardoso JS,Canhao H,Rodrigues AM,Kislaya I,Franco F,Bernardo F,Pimenta J,Mendes L,Gon?alves S,Timóteo AT,Andrade A,Mourau B,Fonseca C,Aguiar C,Brito D,Ferreira J,Azevedo L,Peres M,Santos P,Sarmento PM,Cernadas R,Santos M,Fontes R,Fernandes AC,Martinho H,González JR,Pereira LF,Gil V,Marques CR,Almeida M,Pardal M,Barbosa V,Gavina C. Portuguese Heart Failure Prevalence Observational Study (PORTHOS) rationale and design - A population-based study. Rev Port Cardiol. 2023. 42. (12):p. 985-995. IF:1,800. (4).
