Cost-effectiveness analysis of grass pollen specific immunotherapy in children with allergic rhinitis compared to the standard of care symptomatic treatment in Portugal

Data de publicação:

Autores da FMUP

  • José Luís Dias Delgado

    Autor

  • André Miguel Afonso De Sousa Moreira

    Autor

Participantes de fora da FMUP

  • Farraia, M
  • Paci?ncia, I
  • Mendes, FC
  • Rufo, JC

Unidades de investigação

Abstract

Background. Cost-effectiveness studies evaluating allergen immunothera-py (AIT) in children are scarce. We aim to compare the cost-effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) against stan-dard-of-care (SOC) treatment in children with grass pollen allergic rhinitis. Methods. We created a Markov model to compare the three strategies over a 10-year horizon. SOC was the reference to calculate the incremental cost-ef-fectiveness ratio (ICER). Deterministic and probabilistic sensitivity analysis were used to assess models' uncertainty. Results. We obtained an ICER of 12,605euro and 6,318euro for SLIT and SCIT, respectively. In sensitivity analysis, SCIT was more cost-effective than SLIT. Conclusions. AIT is cost-effective in children with grass pollen allergic rhinitis, especially for the subcutaneous route.

Dados da publicação

ISSN/ISSNe:
1764-1489,

European Annals of Allergy and Clinical Immunology  EDRA S.p.A

Tipo:
Article
Páginas:
212-228
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 1

Citações Recebidas na Scopus: 2

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Keywords

  • Allergen immunotherapy; allergic rhinitis; children; cost-effectiveness; grass pollen

Financiamento

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