Portal de investigação
MicroRNA Biomarkers as Promising Tools for Early Colorectal Cancer Screening-A Comprehensive Review
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Santos, DAR
- Gaiteiro, C
- Santos, M
- Santos, L
- Lima, L
Unidades de investigação
Abstract
Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Early detection of this neoplasia has proven to improve prognosis, resulting in a 90% increase in survival. However, available CRC screening methods have limitations, requiring the development of new tools. MicroRNA biomarkers have emerged as a powerful screening tool, as they are highly expressed in CRC patients and easily detectable in several biological samples. While microRNAs are extensively studied in blood samples, recent interest has now arisen in other samples, such as stool samples, where they can be combined with existing screening methods. Among the microRNAs described in the literature, microRNA-21-5p and microRNA-92a-3p and their cluster have demonstrated high potential for early CRC screening. Furthermore, the combination of multiple microRNAs has shown improved performance in CRC detection compared to individual microRNAs. This review aims to assess the available data in the literature on microRNAs as promising biomarkers for early CRC screening, explore their advantages and disadvantages, and discuss the optimal study characteristics for analyzing these biomarkers.
Dados da publicação
- ISSN/ISSNe:
- 1661-6596, 1661-6596
- Tipo:
- Review
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
International Journal of Molecular Sciences Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 12
Documentos
- Não há documentos
Filiações
Keywords
- microRNA; colorectal cancer; biomarker; screening; early detection
Proyectos asociados
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Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico (IMAGE) . AgênciaD&C . 2021
Effectiveness of endoscopic resection of colonic lesions > 20mm
Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico (Colonic lesions) . 2020
Prevalence and Prognostic Importance of Occult Tumor Cells in Gastric Cancer
Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico . 2022
Citar a publicação
Santos D,Gaiteiro C,Santos M,Santos L,Dinis M,Lima L. MicroRNA Biomarkers as Promising Tools for Early Colorectal Cancer Screening-A Comprehensive Review. Int. J. Mol. Sci. 2023. 24(13):11023. IF:5,600. (1).
