Portal de investigação
Gastric cancer detection by non-blood-based liquid biopsies: A systematic review looking into the last decade of research
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Lopes, C
- Chaves, J
- Ortigao, R
- Pereira, C
Unidades de investigação
Abstract
Gastric cancer (GC) screening is arguable in most Western countries. Liquid biopsies are a great promise to answer the unmet need for less invasive diagnostic biomarkers in GC. Thus, we aimed at systematically reviewing the current knowledge on liquid biopsy-based biomarkers in GC screening. A systematic search on PubMed/MEDLINE and Scopus databases was performed on published articles reporting the use of non-blood specimen (saliva, gastric juice [GJ], urine and stool) on GC diagnosis. 3208 records were retrieved by June 2022. After removal of duplicate records, 2379 abstracts were screened, and 84 full texts included in this systematic review. More than 90% of studies were reported on Asian populations. Overall, 9 studies explored stool-, 12 saliva-, and 29 urine-derived biomarkers for GC detection. Additionally, 37 studies, representing the majority, analyzed GJ, focusing on nucleic acid molecules. Several miRNAs and lncRNA molecules have been associated with GC risk, particularly miR-21 (area under the curve [AUC] = 0.97, 95% CI: 0.94-1.00). Considering salivary biomarkers, the best described model in validation sets included the soybean agglutinin and Vicia villosa agglutinin lectins (AUC = 0.89, 95% CI: 0.80-0.99). Most studies in urine carried out metabolomic approaches, with two discriminatory models presenting AUC values superior to 0.97. This systematic review emphasizes the potential role of non-blood-based biomarkers, although further validation, particularly in Western countries, is mandatory, namely for non-invasive screening and/or monitoring, as well as the use of GJ as a tool to enhance upper gastrointestinal endoscopy accuracy.
© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.
Dados da publicação
- ISSN/ISSNe:
- 2050-6406, 2050-6414
- Tipo:
- Review
- Páginas:
- 114-130
- DOI:
- 10.1002/ueg2.12328
- Link para outro recurso:
- www.scopus.com
United European Gastroenterology Journal John Wiley & Sons Inc.
Citações Recebidas na Web of Science: 6
Citações Recebidas na Scopus: 11
Documentos
- Não há documentos
Filiações
Keywords
- feces; gastric juice; saliva; stomach neoplasms; urine
Financiamento
Proyectos asociados
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Effectiveness of endoscopic resection of colonic lesions > 20mm
Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico (Colonic lesions) . 2020
Prevalence and Prognostic Importance of Occult Tumor Cells in Gastric Cancer
Investigador Principal: Mário Jorge Dinis Ribeiro
Estudo Clínico Académico . 2022
Citar a publicação
Lopes C,Chaves J,Ortigao R,Dinis M,Pereira C. Gastric cancer detection by non-blood-based liquid biopsies: A systematic review looking into the last decade of research. United Eur. Gastroenterol. J. 2023. 11(1):p. 114-130. IF:6,000. (1).
