Gastric Cancer: A Practical Review on Management of Individuals with Hereditary or Familial Risk for Gastric Cancer

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Diogo Miguel Pereira Libânio Monteiro

    Autor

  • Mário Jorge Dinis Ribeiro

    Autor

Participantes de fora da FMUP

  • Linhares, M
  • Pinto, CM
  • Teixeira, M.
  • Brandao, C

Unidades de investigação

Abstract

Gastric adenocarcinoma is one of the most frequent and deadly cancers worldwide. However, its incidence is variable, being higher in eastern countries where screening the general population is recommended. On the other hand, in low to intermediate-risk countries, screening the general population may not be cost-effective, and therefore, it is necessary to be aware of high-risk populations that may benefit from adequate screening and surveillance. It is not always easy to identify these individuals, leading to a late diagnosis of gastric adenocarcinoma. In this review, the authors intend to summarize the data required to identify the population at risk of sporadic or familial gastric adenocarcinoma and the beginning of screening and its surveillance, with the final aim of increasing early detection of gastric adenocarcinoma and decreasing morbimortality. The authors highlight the importance to be aware of the several hereditary syndromes and MAPS recommendations and apply screen and surveillance protocols. The high-risk syndromes to gastric adenocarcinoma are gastric adenocarcinoma and proximal polyposis of the stomach, hereditary diffuse gastric cancer, and familial intestinal gastric cancer.

Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel.

Dados da publicação

ISSN/ISSNe:
2341-4545, 2387-1954

GE Portuguese Journal of Gastroenterology  Karger AG

Tipo:
Review
Páginas:
253-266
Link para outro recurso:
www.scopus.com

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Keywords

  • Gastric cancer; High-risk population; Sporadic cancer risk; Familial cancer risk

Proyectos asociados

Individualized gastric adenocarcinoma early diagnosis and improved patients survival: from liquid biopsies to a comprehensive management approach. (IMAGE)

Investigador Principal: Mário Jorge Dinis Ribeiro

Estudo Clínico Académico (IMAGE) . AgênciaD&C . 2021

Effectiveness of endoscopic resection of colonic lesions > 20mm

Investigador Principal: Mário Jorge Dinis Ribeiro

Estudo Clínico Académico (Colonic lesions) . 2020

Prevalence and Prognostic Importance of Occult Tumor Cells in Gastric Cancer

Investigador Principal: Mário Jorge Dinis Ribeiro

Estudo Clínico Académico . 2022

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