Portal de investigação
Exploring Gunnera tinctoria: From Nutritional and Anti-Tumoral Properties to Phytosome Development Following Structural Arrangement Based on Molecular Docking
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Fathi, F
- Ebrahimi, SN
- Valadao, AIG
- Andrade, N
- Costa, ASG
- Fathi, A
- Salehi, P
- Alves, RC
- Oliveira, MBPP
Unidades de investigação
Abstract
Gunnera tinctoria, an underexplored invasive plant found in Azores, Portugal, was studied regarding its nutritional, antioxidant, and antitumoral properties. Higher antioxidant activity was found in baby leaves, followed by adult leaves and inflorescences. A phenolic fraction of the plant was enriched using adsorbent resin column chromatography (Diaion(TM) HP20LX, and Relite EXA90). Antitumoral effects were observed with the enriched fractions in breast (MCF-7) and pancreatic (AsPC-1) cancer cell lines, being more pronounced in the latter. To improve protection and membrane absorption rates of phenolic compounds, nano-phytosomes and cholesterol-conjugated phytosomes coated with natural polymers were loaded with the enriched fraction. The particles were characterized, and their physiochemical properties were evaluated and compared. All samples presented anionic charge and nanometer size in relation to the inner layer and micrometer size regarding the external layers. In addition, the molecular arrangement of phenolics within both types of phytosomes were studied for the first time by molecular docking. Polarity and molecular size were key factors on the molecular arrangement of the lipid bilayer. In conclusion, G. tinctoria showed to be an interesting source of nutrients and phenolic compounds with anti-tumoral potential. Moreover, phytosome loading with these compounds can increase their stability and bioavailability having in view future applications.
Dados da publicação
- ISSN/ISSNe:
- 1420-3049, 1420-3049
- Tipo:
- Article
- Páginas:
- 5935-
- Link para outro recurso:
- www.scopus.com
Molecules Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 5
Citações Recebidas na Scopus: 10
Documentos
- Não há documentos
Filiações
Keywords
- bioactive compounds; phytosome; secondary layer; molecular docking; bilayer arrangement
Financiamento
Proyectos asociados
The role of EGCG in breast cancer prevention and therapy
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico (EGCG) . 2020
Intestinal fructose absorption: regulation and relation to human diseases
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
The role of the glutamine transporter ASCT2 in antineoplastic therapy
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
The effect of dietary polyphenols upon the intestinal absorption of fructose: relevance for metabolic syndrome
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
Citar a publicação
Fathi F,Ebrahimi SN,Valadao A,Andrade N,Costa A,Silva C,Fathi A,Salehi P,Martel F,Alves RC,Oliveira MBPP. Exploring <i>Gunnera tinctoria</i>: From Nutritional and Anti-Tumoral Properties to Phytosome Development Following Structural Arrangement Based on Molecular Docking. Molecules. 2021. 26. (19):p. 5935-5935. IF:4,927. (2).
