Exhaled breath condensate pH determinants in school-aged children: A population-based study

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Tiago Emanuel Azenha Rama

    Autor

  • Diana Margarida Gonçalves Solha Pereira Da Silva

    Autor

  • José Luís Dias Delgado

    Autor

  • André Miguel Afonso De Sousa Moreira

    Autor

Participantes de fora da FMUP

  • Paciência, I
  • Rufo, JC
  • Cunha, P
  • Severo, M
  • Padrao, P
  • Moreira, P.

Unidades de investigação

Abstract

Background: Exhaled breath condensate (EBC) pH is a promising biomarker of airway inflammation. Lack of method standardization and interstudy variability precludes its use in clinical practice. While endogenous determinants have been described, underlying mechanisms for variability are mostly unknown. Thus, we aimed to assess the association between asthma and EBC pH in children, while studying potential environmental factors for interstudy variability. Methods: A cross-sectional analysis of exhaled breath condensates from 613 children, aged 7-12 years, was conducted. Assessments included lung function and airway reversibility, exhaled nitric oxide, allergic sensitization, and body mass index (BMI). Indoor air quality (IAQ) was assessed in children's classrooms during 5 school days. Post-deaeration EBC pH showed a bimodal distribution, and the sample was split into acidic and alkaline groups. Regression models were constructed to assess the effects of asthma and asthma adjusted to IAQ parameters on EBC pH. Results: Following adjustment to gender and BMI, asthma was significantly associated with a lower EBC pH in the acidic group. The effect of asthma on EBC pH was independent of IAQ, in both groups. In the acidic group, EBC pH was significantly affected by temperature [beta = -0.09 (-0.15, -0.02)] and PM 2.5 concentration [beta = -0.16 (-0.32, -0.01)], and in the alkaline group by relative humidity [beta = 0.07 (0.02, 0.13)] and concentration of endotoxins [beta = -0.06 (-0.1, -0.01)]. Conclusion: Our study shows that in addition to individual determinants such as asthma, environmental factors may influence and should be taken into consideration when interpreting EBC pH level in children.

Dados da publicação

ISSN/ISSNe:
1399-3038, 0905-6157

Pediatric Allergy and Immunology  Blackwell Munksgaard

Tipo:
Article
Páginas:
1474-1481
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 4

Citações Recebidas na Scopus: 7

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Keywords

  • asthma; biomarker; exhaled breath condensate ph; indoor air quality

Financiamento

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