Portal de investigação
Mortality risk prediction in elderly patients with cardiogenic shock: results from the CardShock study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Hongisto, M
- Lassus, J
- Tarvasmäki, T
- Sionis, A
- San Roselló, J
- Tolppanen, H
- Kataja, A
- Jäntti, T
- Sabell, T
- Lindholm, MG
- Banaszewski, M
- Parissis, J
- Di Somma, S
- Carubelli, V
- Jurkko, R
- Masip, J
- Harjola, VP
- CardShock Study In
Unidades de investigação
Abstract
Aims This study aimed to assess the utility of contemporary clinical risk scores and explore the ability of two biomarkers [growth differentiation factor-15 (GDF-15) and soluble ST2 (sST2)] to improve risk prediction in elderly patients with cardiogenic shock. Methods and results Patients (n = 219) from the multicentre CardShock study were grouped according to age (elderly >= 75 years and younger). Characteristics, management, and outcome between the groups were compared. The ability of the CardShock risk score and the IABP-SHOCK II score to predict in-hospital mortality and the additional value of GDF-15 and sST2 to improve risk prediction in the elderly was evaluated. The elderly constituted 26% of the patients (n = 56), with a higher proportion of women (41% vs. 21%, P < 0.05) and more co-morbidities compared with the younger. The primary aetiology of shock in the elderly was acute coronary syndrome (84%), with high rates of percutaneous coronary intervention (87%). Compared with the younger, the elderly had higher in-hospital mortality (46% vs. 33%; P = 0.08), but 1 year post-discharge survival was excellent in both age groups (90% in the elderly vs. 88% in the younger). In the elderly, the risk prediction models demonstrated an area under the curve of 0.75 for the CardShock risk score and 0.71 for the IABP-SHOCK II score. Incorporating GDF-15 and sST2 improved discrimination for both risk scores with areas under the curve ranging from 0.78 to 0.84. Conclusions Elderly patients with cardiogenic shock have higher in-hospital mortality compared with the younger, but post-discharge outcomes are similar. Contemporary risk scores proved useful for early mortality risk prediction also in the elderly, and risk stratification could be further improved with biomarkers such as GDF-15 or sST2.
Dados da publicação
- ISSN/ISSNe:
- 2055-5822, 2055-5822
- Tipo:
- Article
- Páginas:
- 1398-1407
- DOI:
- 10.1002/ehf2.13224
- Link para outro recurso:
- www.scopus.com
ESC heart failure The Heart Failure Association of the European Society of Cardiology
Citações Recebidas na Web of Science: 12
Citações Recebidas na Scopus: 13
Documentos
- Não há documentos
Filiações
Keywords
- Cardiogenic shock; Elderly; Risk prediction; Biomarker; GDF-15; sST2
Financiamento
Proyectos asociados
Registo global de insuficiência cardíaca congestiva.
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo Observacional Académico (IC_Congestiva) . 2019
This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms (EMPERIAL) - NCT03448406
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Ensaio Clínico Comercial (EMPERIAL) . Boehringer Ingelheim . 2020
Envolva-se com o seu coração: Promoção da adesão terapêutica com um sistema de telemonitorização para pessoas com insuficiência cardíaca crónica. (AdHeart)
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo de Intervenção Académico (AdHeart) . FCT . 2019
Sacubitril/Valsartan in everyday clinical practice: the experience of a heart failure clinic
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo Clínico Académico (Sacubitril/Valsartan) . 2020
Avaliação da aorta ascendente em doentes operados a tetralogia de Fallot: implicações no follow-up clínico e imagiológico
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo Clínico Académico . 2020
Hyperkalemia as a limiting factor of Neurohormonal Blockade/Modulation in everyday clinical practice
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo Clínico Académico . 2020
Reversão da remodelagem ventricular na miocardiopatia dilatada idiopática
Investigador Principal: José Carlos de Magalhães Silva Cardoso
Estudo Clínico Académico . 2019
Citar a publicação
Hongisto M,Lassus J,Tarvasmäki T,Sionis A,San Roselló J,Tolppanen H,Kataja A,Jäntti T,Sabell T,Lindholm MG,Banaszewski M,Cardoso JS,Parissis J,Di S,Carubelli V,Jurkko R,Masip J,Harjola VP,CardShock IN. Mortality risk prediction in elderly patients with cardiogenic shock: results from the CardShock study. ESC Heart Fail. 2021. 8. (2):p. 1398-1407. IF:3,612. (2).
