The role of the glutamine transporter ASCT2 in antineoplastic therapy

Autores da FMUP
Participantes de fora da FMUP
- Teixeira, E
Unidades de investigação
Abstract
Cancer cells are metabolically reprogrammed to support their high rates of proliferation, continuous growth, survival, invasion, metastasis, and resistance to cancer treatments. Among changes in cancer cell bioenergetics, the role of glutamine metabolism has been receiving increasing attention. Increased glutaminolysis in cancer cells is associated with increased expression of membrane transporters that mediate the cellular uptake of glutamine. ASCT2 (Alanine, Serine, Cysteine Transporter 2) is a Na+-dependent transmembrane transporter overexpressed in cancer cells and considered to be the primary transporter for glutamine in these cells. The possibility of inhibiting ASCT2 for antineoplastic therapy is currently under investigation. In this article, we will present the pharmacological agents currently known to act on ASCT2, which have been attracting attention in antineoplastic therapy research. We will also address the impact of ASCT2 inhibition on the prognosis of some cancers. We conclude that ASCT2 inhibition and combination of ASCT2 inhibitors with other anti-tumor therapies may be a promising antineoplastic strategy. However, more research is needed in this area.
Dados da publicação
- ISSN/ISSNe:
- 1432-0843, 0344-5704
- Tipo:
- Review
- Páginas:
- 447-464
- Link para outro recurso:
- www.scopus.com
Cancer Chemotherapy and Pharmacology Springer Verlag
Citações Recebidas na Web of Science: 20
Citações Recebidas na Scopus: 34
Documentos
- Não há documentos
Filiações
Keywords
- Antineoplastic therapy; ASCT2; Glutamine uptake; Metabolic reprogramming
Proyectos asociados
The role of EGCG in breast cancer prevention and therapy
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico (EGCG) . 2020
Intestinal fructose absorption: regulation and relation to human diseases
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
The role of the glutamine transporter ASCT2 in antineoplastic therapy
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
The effect of dietary polyphenols upon the intestinal absorption of fructose: relevance for metabolic syndrome
Investigador Principal: Maria de Fátima Moreira Martel
Estudo Clínico Académico . 2020
Citar a publicação
Teixeira E,Silva C,Martel F. The role of the glutamine transporter ASCT2 in antineoplastic therapy. Cancer Chemother. Pharmacol. 2021. 87(4):p. 447-464. IF:3,288. (3).