Portal de investigação
Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock - Insights from the CardShock study
Autores da FMUP
Participantes de fora da FMUP
- Kataja, A
- Tarvasmäki, T
- Lassus, J
- Sionis, A
- Mebazaa, A
- Pulkki, K
- Banaszewski, M
- Carubelli, V
- Hongisto, M
- Jankowska, E
- Jurkko, R
- Jäntti, T
- Kasztura, M
- Parissis, J
- Sabell, T
- Spinar, J
- Tolppanen, H
- Harjola, VP
- CardShock Investigators
Unidades de investigação
Abstract
Background: Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods: Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0-120h) from 183 patients in the CardShock study. The study population was dichotomized by PCTmax >= and < 0.5 mu g/L, and IL-6 and CRPmax above/below median. Results: PCT peaked already at 24 h [median PCTmax 0.71 mu g/L (IQR 0.24-3.4)], whereas CRP peaked later between 48 and 72 h [median CRPmax 137mg/L (59-247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on (p < 0.001). PCTmax >= 0.5 mu g/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRPmax. Similarly, IL-6 > median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCTmax >= 0.5 mu g/L and IL-6 > median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p < 0.01 for both), while CRPmax showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions: Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis. (C) 2020 Elsevier B.V. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 1874-1754, 0167-5273
- Tipo:
- Article
- Páginas:
- 191-196
- Link para outro recurso:
- www.scopus.com
International Journal of Cardiology Elsevier Ireland Ltd
Citações Recebidas na Web of Science: 10
Citações Recebidas na Scopus: 16
Documentos
- Não há documentos
Filiações
Keywords
- Cardiogenic shock; Inflammation; Procalcitonin; Interleukin 6; C-reactive protein
Financiamento
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Citar a publicação
Kataja A,Tarvasmäki T,Lassus J,Sionis A,Mebazaa A,Pulkki K,Banaszewski M,Carubelli V,Hongisto M,Jankowska E,Jurkko R,Jäntti T,Kasztura M,Parissis J,Sabell T,Silva J,Spinar J,Tolppanen H,Harjola VP,CardShock I. Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock - Insights from the CardShock study. Int. J. Cardiol. 2021. 322. p. 191-196. IF:4,039. (2).
