Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation

Data de publicação:

Autores da FMUP

  • Maria De Fátima Moreira Martel

    Autor

  • Cláudia Raquel Santos Silva

    Autor

Participantes de fora da FMUP

  • Ferreira, BJML
  • Santos, TM
  • Daniel da Silva, AL

Unidades de investigação

Abstract

Cisplatin has demonstrated extraordinary anticancer activity against a variety of solid tumors. However, its clinical efficacy is contrasted by its toxicity profile. Having in mind the need to reduce the toxicity, promote a sustained release and enhance the body-circulation time of cisplatin, herein novel nanocarriers consisting of core-shell silica-coated iron oxide nanoparticles functionalized with dicarboxylic acid groups were prepared and characterized. Cisplatin was conjugated with the functionalized nanoparticles by surface tethering. Controlled release of cisplatin was observed without burst effect and in a sustained profile for up to 3 days. In vitro studies showed cytotoxic and antiproliferative effects of the cisplatin nanoconjugates against a human pancreatic cancer cell line. Importantly, when compared with free cisplatin, nanoconjugates exhibited lower cytotoxic effects regarding nonmalignant human duct pancreatic cells.

Dados da publicação

ISSN/ISSNe:
0162-0134, 1873-3344

Journal of Inorganic Biochemistry  Elsevier Inc.

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 15

Citações Recebidas na Scopus: 17

Documentos

  • Não há documentos

Filiações mostrar / ocultar

Keywords

  • Cisplatin; Iron oxide nanoparticles; Cisplatin nanoconjugates; Pancreatic cancer; Cisplatin sustained release; In vitro cytotoxicity

Financiamento

Proyectos asociados

The role of EGCG in breast cancer prevention and therapy

Investigador Principal: Maria de Fátima Moreira Martel

Estudo Clínico Académico (EGCG) . 2020

Intestinal fructose absorption: regulation and relation to human diseases

Investigador Principal: Maria de Fátima Moreira Martel

Estudo Clínico Académico . 2020

The role of the glutamine transporter ASCT2 in antineoplastic therapy

Investigador Principal: Maria de Fátima Moreira Martel

Estudo Clínico Académico . 2020

The effect of dietary polyphenols upon the intestinal absorption of fructose: relevance for metabolic syndrome

Investigador Principal: Maria de Fátima Moreira Martel

Estudo Clínico Académico . 2020

Citar a publicação

Partilhar a publicação