Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation

Autores da FMUP

• Maria De Fátima Moreira Martel

  Autor

• Cláudia Raquel Santos Silva

  Autor

Participantes de fora da FMUP

• Ferreira, BJML
• Santos, TM
• Daniel da Silva, AL

Unidades de investigação

• Biomedicina

Abstract

Cisplatin has demonstrated extraordinary anticancer activity against a variety of solid tumors. However, its clinical efficacy is contrasted by its toxicity profile. Having in mind the need to reduce the toxicity, promote a sustained release and enhance the body-circulation time of cisplatin, herein novel nanocarriers consisting of core-shell silica-coated iron oxide nanoparticles functionalized with dicarboxylic acid groups were prepared and characterized. Cisplatin was conjugated with the functionalized nanoparticles by surface tethering. Controlled release of cisplatin was observed without burst effect and in a sustained profile for up to 3 days. In vitro studies showed cytotoxic and antiproliferative effects of the cisplatin nanoconjugates against a human pancreatic cancer cell line. Importantly, when compared with free cisplatin, nanoconjugates exhibited lower cytotoxic effects regarding nonmalignant human duct pancreatic cells.

Keywords

• Cisplatin; Iron oxide nanoparticles; Cisplatin nanoconjugates; Pancreatic cancer; Cisplatin sustained release; In vitro cytotoxicity