Portal de investigação
Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort)
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Lorthe, E
- Moreira, C
- Weber, T
- Huusom, LD
- Schmidt, S
- Maier, RF
- Jarreau, PH
- Cuttini, M
- Draper, ES
- Zeitlin, J
- EPICE Res Grp
Unidades de investigação
Abstract
After preterm premature rupture of membranes (PPROM), antibiotics and antenatal steroids are effective evidence-based interventions, but the use of tocolysis is controversial. We investigated whether a unit policy of tocolysis use after PPROM is associated with prolonged gestation and improved outcomes for very preterm infants in units that systematically use these other evidence-based treatments. From the prospective, observational, population-based EPICE cohort study (all very preterm births in 19 regions from 11 European countries, 2011-2012), we included 607 women with a singleton pregnancy and PPROM at 24-29 weeks' gestation, of whom 101, 195 and 311 were respectively managed in 17, 32 and 45 units with no-use, restricted and liberal tocolysis policies for PPROM. The association between unit policies and outcomes (early-onset sepsis, survival at discharge, survival at discharge without severe morbidity and survival at two years without gross motor impairment) was investigated using three-level random-intercept logistic regression models, showing no differences in neonatal or two-year outcomes by unit policy. Moreover, there was no association between unit policies and prolongation of gestation in a multilevel survival analysis. Compared to a unit policy of no-use of tocolysis after PPROM, a liberal or restricted policy is not associated with improved obstetric, neonatal or two-year outcomes.
Dados da publicação
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Scientific Reports Nature Publishing Group
Citações Recebidas na Web of Science: 2
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- PRELABOR RUPTURE; CLINICAL-PRACTICE; MANAGEMENT; BIRTH; TOCOLYTICS; LABOR
Financiamento
Proyectos asociados
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
Lorthe E,Moreira C,Weber T,Huusom LD,Schmidt S,Maier RF,Jarreau PH,Cuttini M,Draper ES,Zeitlin J,Barros H,EPICE GRP. Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort). Sci. Rep. 2020. 10. (1):9535. IF:4,379. (1).
