Portal de investigação
Characterization and LDL-C management in a cohort of high and very high cardiovascular risk patients: The PORTRAIT-DYS study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Seabra-Carvalho, D
- Aguiar, C
- Anastassopoulou, A
- Teixeira, C
- Ruivo, JA
- Almeida, E
- Luz-Duarte, L
- Corte-Real, A
- Canelas-Pais, M
Unidades de investigação
Abstract
AimThis study aims to characterize sociodemographic and clinical characteristics, use of lipid-lowering therapies (LLTs), and low-density lipoprotein cholesterol (LDL-C) control in a population with increased cardiovascular (CV) risk.MethodsA cross-sectional observational study that uses electronic health records of patients from one hospital and across 14 primary care health centers in the North of Portugal, spanning from 2000 to 2020 (index date). Patients presented at least (i) 1 year of clinical data before inclusion, (ii) one primary care appointment 3 years before the index date, and (iii) sufficient data for CV risk classification. Patients were divided into three cohorts: high CV risk; atherosclerotic cardiovascular disease (ASCVD) risk equivalents without established ASCVD; evidence of ASCVD. CV risk and LDL-C control were defined by the 2019 and 2016 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidemia guidelines.ResultsA total of 51 609 patients were included, with 23 457 patients classified as high CV risk, 19 864 with ASCVD equivalents, and 8288 with evidence of ASCVD. LDL-C control with 2016 ESC/EAS guidelines was 32%, 10%, and 18% for each group, respectively. Considering the ESC/EAS 2019 guidelines control level was even lower: 7%, 3%, and 7% for the same cohorts, respectively. Patients without any LLT prescribed ranged from 37% in the high CV risk group to 15% in patients with evidence of ASCVD.ConclusionWe found that LDL-C control was very low in patients at higher risk of CV events. An alarming gap between guidelines on dyslipidemia management and clinical implementation persists, even in those at very high risk or with established ASCVD. We analyzed electronic health records of 51 609 patients from one hospital and 14 primary care centers in Portugal, assessing sociodemographic and clinical characteristics, lipid-lowering therapies usage, and low-density lipoprotein cholesterol (LDL-C) control. Our findings show suboptimal LDL-C control in high-risk patients, emphasizing the need for improved strategies.image
Dados da publicação
- ISSN/ISSNe:
- 1932-8737, 0160-9289
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1002/clc.24183
- Link para outro recurso:
- www.scopus.com
Clinical Cardiology Wiley-Blackwell
Citações Recebidas na Scopus: 1
Documentos
- Não há documentos
Filiações
Keywords
- atherosclerosis; cardiovascular risk; cholesterol; computerized; hypolipidemic agents; LDL; medical records systems
Financiamento
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Citar a publicação
Gavina C,Seabra D,Aguiar C,Anastassopoulou A,Teixeira C,Ruivo JA,Almeida E,Luz L,Corte A,Canelas M,Taveira T. Characterization and LDL-C management in a cohort of high and very high cardiovascular risk patients: The PORTRAIT-DYS study. Clin. Cardiol. 2023. 47. (1):e24183. IF:2,700. (3).
