Portal de investigação
Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Santos, MMS
- Pereira, IJ
- Cuboia, N
- Reis-Pardal, J
- Adriao, D
- Cardoso, T
- Aragao, I
- Santos, L
- Sarmento, A.
- Rosa, RG
- Teixeira, C
Unidades de investigação
Abstract
Background To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy.Methods In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients.Results We observed an overall ICU mortality of 20.1% [95%CI: 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI: 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI: 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI: 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge: hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality.Conclusion Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy.
Dados da publicação
- ISSN/ISSNe:
- 1932-6203, 1932-6203
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
PLoS ONE Public Library of Science
Citações Recebidas na Scopus: 2
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Filiações
Keywords
- INTENSIVE-CARE
Financiamento
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Citar a publicação
Santos MMS,Pereira IJ,Cuboia N,Reis J,Adriao D,Cardoso T,Aragao I,Santos L,Sarmento A,Rosa RG,Granja C,Teixeira C,Azevedo L. Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study. PLoS ONE. 2023. 18. (11):e0293883. IF:3,700. (2).
