Portal de investigação
Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic-Pituitary-Thyroid Axis
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Azeredo, DBC
- Anselmo, DD
- Graceli, JB
- Magliano, DC
- Miranda Alves, L
Unidades de investigação
Abstract
Parabens are classified as endocrine-disrupting chemicals (EDCs) capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (THs), which is controlled by the hypothalamic-pituitary-thyroid axis (HPT). Given the crucial role of these hormones in health and the growing evidence of diseases related to thyroid dysfunction, this review looks at the effects of paraben exposure on the thyroid. In this study, we considered research carried out in vitro and in vivo and epidemiological studies published between 1951 and 2023, which demonstrated an association between exposure to parabens and dysfunctions of the HPT axis. In humans, exposure to parabens increases thyroid-stimulating hormone (TSH) levels, while exposure decreases TSH levels in rodents. The effects on THs levels are also poorly described, as well as peripheral metabolism. Regardless, recent studies have shown different actions between different subtypes of parabens on the HPT axis, which allows us to speculate that the mechanism of action of these parabens is different. Furthermore, studies of exposure to parabens are more evident in women than in men. Therefore, future studies are needed to clarify the effects of exposure to parabens and their mechanisms of action on this axis.
Dados da publicação
- ISSN/ISSNe:
- 1661-6596, 1661-6596
- Tipo:
- Review
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
International Journal of Molecular Sciences Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 12
Documentos
- Não há documentos
Filiações
Keywords
- parabens; toxicity; thyroid; endocrine disruptor; hypothalamus-pituitary-thyroid axis
Financiamento
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Citar a publicação
Azeredo DBC,Anselmo DD,Soares Dias Ferreira A,Graceli JB,Magliano DC,Miranda L. Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic-Pituitary-Thyroid Axis. Int. J. Mol. Sci. 2023. 24(20):15246. IF:5,600. (1).
