Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper

Data de publicação: 22/08/2023 Data Ahead of Print: 01/08/2023

Autores da FMUP

Fernando José Magro Dias

Autor

Participantes de fora da FMUP

Feakins, R
Nunes, PB
Driessen, A
Gordon, IO
Zidar, N
Baldin, P
Christensen, B
Danese, S
Herlihy, N
Iacucci, M
Loughrey, MB
Mookhoek, A
Svrcek, M
Rosini, F

Unidades de investigação

Biomedicina
Laboratório Associado RISE- Rede de Investigação em Saúde

Investigador

Fernando Carlos De Landér Schmitt
RISE-Health

Investigador

Fernando Carlos De Landér Schmitt

Abstract

Histological assessment of endoscopic biopsies in inflammatory bowel disease [IBD] plays an important role in clinical management, investigative studies, and clinical trials. Scoring schemes consisting of multiple histological items and offering considerable precision are widely available. However, definitions of histological abnormalities are often inconsistent. Furthermore, interobserver variability for their recognition and assessment may be high.The European Crohn's and Colitis Organisation [ECCO] formed an expert panel to explore definitions of histological abnormalities in IBD, with the aim of improving the quality of diagnosis and facilitating development of scoring schemes. The process confirmed that the current definitions often have no evidence base and vary between sources. Using available evidence and expert knowledge, the panel produced a series of ECCO consensus position statements on histological features in IBD.