Portal de investigação
Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Monzo, L
- Lamiral, Z
- Bozec, E
- Boivin, J
- Huttin, O
- Lopez?Sublet, M
- Girerd, N
- Zannad, F
- Rossignol, PAB -
Unidades de investigação
Abstract
Background Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) >= 80 mmHg and systolic blood pressure (SBP) <130 mmHg according to 2017 ACC/AHA guidelines. The effective cardiovascular risk linked to IDH is debated. Hypothesis IDH might contribute marginally to hypertension-related target organ damage (TOD) development. Methods In this cross-sectional analysis 1605 subjects from the STANISLAS cohort, a large familiar longitudinal study from Eastern France, were included. Participants were categorized according to average values at 24-h ABP recording as having normal BP (SBP < 130/DBP < 80 mmHg); combined hypertension (SBP >= 130/DBP >= 80 mmHg or on antihypertensive treatment); IDH (SBP 80 mmHg); isolated systolic hypertension (ISH: SBP >= 130/DBP <80 mmHg). The association between hypertension status and TOD was assessed by multivariable-adjusted logistic models. Results Using normotension as reference, IDH was not significantly associated with NTproBNP levels (adjusted odds ratio [OR] 1.04 [95%CI 0.82;1.32], p = .750), microalbuminuria (OR 0.99 [0.69; 1.42], p = .960), diastolic dysfunction (OR 1.53 [0.88; 2.68], p = .130), left ventricular (LV) mass index (OR per 10 g/m(2) increase 1.07 [0.95; 1.21], p = .250), LV longitudinal strain (global: OR 1.07 [0.99; 1.14], p = .054; subendocardial: OR 1.06 [0.99; 1.13], p = .087), carotid intima media thickness (OR 1.27 [0.79; 2.06], p = .320), reduced ankle-brachial index (<0.9; OR 1.59 [0.19; 13.55], p = .670) and pulse wave velocity (PWV; OR 1.07 [0.93; 1.23], p = .360). In contrast, combined hypertension and ISH were independently associated with LV mass index and PWV increase (all p <= .01). Conclusions IDH was not significantly associated with TOD. Further studies are needed to clarify the clinical role of IDH. Registration: URL: ; Unique identifier: NCT01391442.
Dados da publicação
- ISSN/ISSNe:
- 1932-8737, 0160-9289
- Tipo:
- Article
- Páginas:
- 1516-1525
- DOI:
- 10.1002/clc.23713
- Link para outro recurso:
- www.scopus.com
Clinical Cardiology Wiley-Blackwell
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 5
Documentos
- Não há documentos
Filiações
Keywords
- ambulatory blood pressure; isolated diastolic hypertension; target organ damage
Financiamento
Proyectos asociados
Dapagliflozin, Spironolactone or Both for HFpEF (SOGALDI-PEF) - NCT05676684
Investigador Principal: João Pedro Melo Marques Pinho Ferreira
Ensaio Clínico Académico (SOGALDI-PEF) . AstraZeneca . 2022
Citar a publicação
Monzo L,Ferreira J,Lamiral Z,Bozec E,Boivin J,Huttin O,Lopez?Sublet M,Girerd N,Zannad F,Rossignol P-. Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort. Clin. Cardiol. 2021. 44. (11):p. 1516-1525. IF:3,287. (3).
