Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium

Data de publicação:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Collatuzzo, G
  • Teglia, F
  • Pelucchi, C
  • Negri, E
  • Rabkin, CS
  • Liao, LM
  • Sinha, R
  • López-Carrillo, L
  • Morais, S
  • Aragonés, N
  • Moreno, V
  • Vioque, J
  • de la Hera, MG
  • Ward, MH
  • Malekzadeh, R
  • Pakseresht, M
  • Hernández-Ramírez, RU
  • López-Cervantes, M
  • Bonzi, R
  • Dalmartello, M
  • Tsugane, S
  • Hidaka, A
  • Camargo, MC
  • Curado, MP
  • Zhang, ZF
  • Zubair, N
  • La Vecchia, C
  • Shah, S
  • Boffetta, P

Unidades de investigação

Abstract

Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83-0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77-0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81-0.94), and for diffuse (OR = 0.79, 95% CI = 0.69-0.89) and intestinal type (OR = 0.88, 95% CI = 0.79-0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis.

Dados da publicação

ISSN/ISSNe:
2072-6643, 2072-6643

Nutrients  Multidisciplinary Digital Publishing Institute (MDPI)

Tipo:
Article
Páginas:
2555-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 3

Citações Recebidas na Scopus: 7

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Keywords

  • gastric cancer; iron; diet; cancer subtypes; cancer subsites

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Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

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Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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