Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case-Only Analysis within the Stomach Cancer Pooling (StoP) Project

Data de publicação:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Morais, S
  • Peleteiro, B.
  • Ara?jo, N.
  • Malekzadeh, R
  • Ye, WM
  • Plymoth, A
  • Tsugane, S
  • Hidaka, A
  • Hamada, GS
  • Lopez Carrillo, L
  • Zaridze, D
  • Maximovich, D
  • Aragones, N
  • Castano Vinyals, G
  • Pakseresht, M
  • Hernandez Ramirez, RU
  • Lopez Cervantes, M
  • Leja, M
  • Gasenko, E
  • Pourfarzi, F
  • Zhang, ZF
  • Yu, GP
  • Derakhshan, MH
  • Pelucchi, C
  • Negri, E
  • La Vecchia, C

Unidades de investigação

Abstract

Background: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection. We estimated the proportion of HpNGC, using different criteria to define infection status, and compared HpNGC and positive cases regarding gastric cancer risk factors. Methods: Cases from 12 studies from the Stomach cancer Pooling (StoP) Project providing data on H. pylori infection status determined by serologic test were included. HpNGC was reclassified as positive (eight studies) when cases presented CagA markers (four studies), gastric atrophy (six studies), or advanced stage at diagnosis (three studies), and were compared with positive cases. A two-stage approach (random-effects models) was used to pool study-specific prevalence and adjusted odds ratios (OR). Results: Among non-cardia cases, the pooled prevalence of HpNGC was 22.4% (n = 166/853) and decreased to 7.0% (n = 55) when considering CagA status; estimates for all criteria were 21.8% (n = 276/1,325) and 6.6% (n = 97), respectively. HpNGC had a family history of gastric cancer more often [OR = 2.18; 95% confidence interval (CI), 1.03-4.61] and were current smokers (OR = 2.16; 95% CI, 0.52-9.02). Conclusion: This study found a low prevalence of HpNGC, who are more likely to have a family history of gastric cancer in first-degree relatives. Impact: Our results support that H. pylori infection is present in most non-cardia gastric cancers, and suggest that HpNGC may have distinct patterns of exposure to other risk factors.

Dados da publicação

ISSN/ISSNe:
1055-9965, 1538-7755

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION  American Association for Cancer Research Inc.

Tipo:
Article
Páginas:
200-209
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 5

Citações Recebidas na Scopus: 8

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Keywords

  • RISK-FACTORS; SOCIOECONOMIC POSITION; JAPANESE BRAZILIANS; TOBACCO SMOKING; POOLED ANALYSES; PUBLISHED DATA; INFECTION; CARCINOGENESIS; METAANALYSES; CONSUMPTION

Campos de estudo

Proyectos asociados

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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