Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Collatuzzo, G
  • Alicandro, G
  • Bertuccio, P
  • Pelucchi, C
  • Bonzi, R
  • Palli, D
  • Ferraroni, M
  • Ye, WM
  • Plymoth, A
  • Zaridze, D
  • Maximovich, D
  • Aragones, N
  • Castano Vinyals, G
  • Vioque, J
  • de la Hera, MG
  • Zhang, ZF
  • Hu, JF
  • Lopez Carrillo, L
  • Lopez Cervantes, M
  • Dalmartello, M
  • Mu, LN
  • Ward, MH
  • Rabkin, C
  • Yu, GP
  • Camargo, MC
  • Curado, MP
  • Negri, E
  • La Vecchia, C
  • Boffetta, P

Unidades de investigação

Abstract

Background Peptic ulcer disease (PUD) and gastric cancer (GC) are more prevalent in individuals with low socioeconomic status (SES) and share several risk factors. The aim of this study was to investigate the mediating role of PUD in the association between established risk factors and GC. Methods We conducted a pooled analysis of 12 studies from the Stomach Cancer Pooling Project Consortium, including a total of 4877 GC cases and 11 808 controls. We explored the mediating role of PUD in the association between SES, tobacco smoking, heavy alcohol drinking and salt intake, and GC. Also, we assessed the ORs and 95% CIs of the risk factors and both PUD and GC. Results PUD mediated 36% of the smoking effect mainly among men. Other risk factors were only slightly mediated by PUD (SES, 5.3%; heavy alcohol drinking, 3.3%; and salt intake, 2.5%). No significant difference was found when excluding PUD diagnosed within 2 years from GC. Conclusions Our study provides innovative information on the mechanism of stomach mucosal damage leading to PUD and GC, with respect to the effect of tobacco smoking in particular.

Dados da publicação

ISSN/ISSNe:
1470-2738, 0143-005X

Journal of Epidemiology and Community Health  BMJ Publishing Group

Tipo:
Article
Páginas:
861-866
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 6

Citações Recebidas na Scopus: 11

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Keywords

  • Gastric cancer; Peptic ulcer disease; Mediation analysis; Smoking; Socioeconomic status; Alcohol; Salt

Campos de estudo

Proyectos asociados

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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