NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Autores da FMUP

• Maria De Fátima Moreira Martel

  Autor

Participantes de fora da FMUP

• Santos, ACF
• Monteiro, LPG
• Gomes, ACC
• Santos, TM
• Ferreira, BJML

Unidades de investigação

• Biomedicina

Abstract

After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.

Keywords

• NSAID-based coordination compounds; first-row transition metals; anti-tumor activity; antimicrobial properties; antioxidant activity; interaction with biomolecules; DNA; RNA; proteins