Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and cardiometabolic parameters and agreement for pre-diabetes diagnosis in patients with morbid obesity

Data de publicação:

Autores da FMUP

  • João Sérgio De Lima Soares Neves

    Autor

  • Carla Susana Fernandes Da Costa De Araújo

    Autor

  • Davide Maurício Costa Carvalho

    Autor

Participantes de fora da FMUP

  • Gon?alves, V.
  • Maia, I
  • Salazar, D
  • Ferreira, MJ
  • Mendonca, F
  • Silva, MM
  • Canha, M.
  • Viana, S
  • Pedro, J
  • Varela, A
  • Gouveia, E.
  • Sim?es Freitas, P.

Unidades de investigação

Abstract

Background One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with cardiometabolic risk markers and the level of agreement for prediabetes mellitus diagnosis, in a sample of patients with morbid obesity. Methods We retrospectively evaluated 656 patients with morbid obesity without diagnosed diabetes. To define prediabetes with 2hPG, 2022 American Diabetes Association guidelines criteria were used, while for 1hPG, glucose >= 155 mg/dL was considered. Cohens Kappa coefficient was used to assess the agreement between both measures of prediabetes mellitus diagnosis. Results A Cohens Kappa coefficient of 0.405 (p < 0.001) was obtained. The 1hPG were positively correlated with homeostatic model assessment for insulin resistance (HOMA-IR) (rho = 0.281, p < 0.001), fasting plasma glucose (FPG) (rho = 0.581, p < 0.001), glycated haemoglobin (Hb1AC) (rho = 0.347, p < 0.001) and were negatively correlated with homeostatic model assessment for cell-beta function (HOMA-beta) (rho = -0.092, p = 0.018). 2hPG were also correlated with the same parameters, except for HOMA-beta. Conclusion A fair agreement between 1 and 2hPG was verified. 1hPG criteria may be a useful indicator of beta-cell dysfunction and insulin resistance in patients with morbid obesity without diabetes diagnosis.

Dados da publicação

ISSN/ISSNe:
1758-5996, 1758-5996

DIABETOLOGY & METABOLIC SYNDROME  BioMed Central Ltd.

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 4

Citações Recebidas na Scopus: 4

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Keywords

  • Oral glucose tolerance testing; Prediabetes mellitus; Obesity

Proyectos asociados

Evaluation of thyroid function in patients hospitalized for acute heart failure

Investigador Principal: João Sérgio de Lima Soares Neves

Estudo Clínico Académico (Heart failure) . 2021

Predictors Of The Effectiveness Of Insulin Pumps In Patiens With Type 1 Diabetes Mellitus

Investigador Principal: João Sérgio de Lima Soares Neves

Estudo Clínico Académico . 2021

Diabetic Neuropathy, Central Nervous System Plasticity and Metabolic Disfunction

Investigador Principal: Davide Maurício Costa Carvalho

Estudo Clínico Académico . 2020

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