Bariatric Surgery Impact on Cardiovascular Risk Factors: Is Age a Factor to Consider?

Autores da FMUP

• Vanessa Alexandra Guerreiro Gonçalves

  Autor

• João Sérgio De Lima Soares Neves

  Autor

• Paula Isabel Marques Simões De Freitas

  Autor

• Davide Maurício Costa Carvalho

  Autor

Participantes de fora da FMUP

• Mendon?a, F
• Silva, MM
• Salazar, D
• Correia, F.
• Pedro, J
• Viana, S
• Belo, S
• Varela, A

Unidades de investigação

• Cirurgia e Fisiologia

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Introduction: Despite the abundance of data addressing the influence of patients age on surgery-related complications, its impact on cardiometabolic outcomes following bariatric surgery has been overlooked. Methods: Retrospective unicentric study of 1,728 obese patients who underwent bariatric surgery between January 2010 and June 2015. Patients were divided in 3 age groups, according to their age at surgery: ?40 (n = 751), 40-59 (n = 879), and ?60 years (n = 98). Parameters with cardiometabolic impact, such as body anthropometric measures, lipid profile, and glycemic status, before and 24 months after surgery, were compared between these groups. A multiple linear regression was performed, adjusting differences between groups for sex, surgery type, and body mass index variation. Results: The group ?40 years presented more weight loss (-35.4 ? 9.0 kg, p ? 0.001), greater BMI reduction (-15.8 ? 6.1 kg/m2, p ? 0.001), and larger changes in waist (-34 ? 13.8 cm, p ? 0.001) and hip circumferences (-28.7 ? 11.9 cm, p ? 0.05). The group of ?60 years presented the heaviest reduction in fasting glucose (-17.7 ? 32.8 mg/dL, p ? 0.001) and HbA1c (0.7 ? 1.0, p ? 0.001), and also had a tendency to have the biggest changes in systolic blood pressure (-14.7 ? 18.7 mm Hg, p = 0.071). Conclusion: Patients with ?60 years benefit the most from bariatric surgery regarding cardiometabolic parameters, presenting heavier reductions in fasting glucose, as well as HbA1c and a tendency towards a higher decrease in systolic blood pressure. No clinically significant differences in lipid profile were observed between groups. ? 2020

Keywords

• Weight loss; Diabetes mellitus; Dyslipidemia; Bariatric surgery; Hypertension; Age; Outcomes