Terson Syndrome-Clinical Presentation, Management, and Visual Outcomes in a Tertiary Centre

Autores da FMUP

• Fernando Manuel Mendes Falcão Reis

  Autor

• Amândio António Rocha Dias De Sousa

  Autor

Participantes de fora da FMUP

• Lima Fontes, M
• Leuzinger Dias, M
• Rodrigues, R
• Barros Pereira, R
• Falc?o, M.
• Fernandes, V
• Alves Faria, P

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Purpose: The purpose of this study was to characterize the clinical presentation, management strategy and visual outcomes of patients diagnosed with Terson syndrome and followed in a tertiary centre in Portugal. Patients and Methods: A single-centre retrospective study was performed, based on the survey review of the medical records of every consecutive patient diagnosed with Terson syndrome and followed from January 2018 to August 2021. The change in bestcorrected visual acuity (BCVA) from baseline to the final evaluation was the primary outcome. Results: Fifteen eyes from 8 patients (50% female) were included. The mean age at diagnosis was 55 +/- 7 years. The neurological event was traumatic brain injury in 37.5% (n=3) and subarachnoid haemorrhage in 62.5% of the patients (n=5). Bilateral intraocular haemorrhage occurred in 875% (n=7) of the patients. Vitreous and preretinal haemorrhages occurred each in 66.7% (n=10), intraretinal in 30% (n=3) and subretinal in 13.3% (n=2) of the eyes. In 40% of the eyes (n=6), spontaneous resolution of intraocular haemorrhage occurred, while PPV was performed in the remaining 60% (n=9). Ocular haemorrhage detection occurred 58.47 +/- 40.94 days after the neurological event (range 11 to 121 days). Baseline BCVA was 1.11 +/- 1.01 logMAR and improved to 0.32 +/- 0.69 logMAR in the follow-up period (p=0.004). A positive correlation was found between initial and final BCVA (Spearmans rho = 0.643, p=0.01). Baseline BCVA of eyes undergoing PPV was lower than of those conservatively managed (1.84 +/- 0.72 vs 0.20 +/- 0.28 logMAR, p<0.001). However, there were no statistically significant differences in final BCVA after surgery or observation (0.56 +/- 0.90 vs 0.04 +/- 0.04 logMAR, p=0.149). Longer periods between the neurological and the ophthalmological diagnosis were correlated with worse final BCVA (Spearmans rho = 0.688, p=0.005). Conclusion: Terson syndrome is a potential cause of irreversible visual loss. Diagnosis delay may affect visual prognosis. PPV is indicated when intraocular haemorrhage is dense and does not resolve spontaneously or when visual acuity at presentation is low, allowing for good visual outcomes with minimal complications.

Keywords

• Terson syndrome; management; vitrectomy; visual outcomes; clinical presentation