Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Data de publicação: 01/01/2021

Autores da FMUP

Elsa Irene Peixoto Azevedo Silva

Autor

Participantes de fora da FMUP

Monti, S
Klersy, C
Montecucco, C
Caporali, R
Watts, R
Luqmani, R
Achilleos, K
Adler, M
Alba, MA
Albert, DA
Alibaz-Oner, F
Allcoat, P
Amano, K
Amarasuriya, M
Amudala, NA
Andrews, J
Archer, AM
Arimura, Y
Atukorala, I
Bajad, S
Baldwin, C
Barra, LJ
Baslund, B
Basu, N
Baykal, M
Berger, C
Berglin, E
Besada, E
Bhardwaj, M
Bischof, A
Blockmans, D
Blood, J
Draibe, JB
Brand, S
Brandao, M
Bruce, IN
Butler, A
Calabrese, LH
Ferrer, DC
Carette, S
Carmona, D
Ceunen, H
Chakravarty, K
Chapman, PT
Chocova, Z
Chung, SA
Ci, W
Cid, MC
Clark, TM
Clarkson, MR
de Jesus Contreras-Rodr?guez, F
Conway, R
Cooke, K
Vir?s, XC
Cordeiro, A
Costa, A
Craven, A
Culfear, K
Daikeler, T
Danda, D
Das, SK
Dasgupta, B
De Castro, AM
Dehghan, N
Devassy, R
Dhindsa, N
Diamantopoulos, AP
Direskeneli, H
Dobashi, H
Juan, D
Durrani, M
Edelsten, C
Eifert, J
Elhayek, S
Elsideeg, S
Endo, T
Erden, A
Erer, B
Eriksson, P
Erturk, Z
Esp?gol-Frigol?, G
Felicetti, M
Ferraro, A
Ferro, JM
Fifi-Mah, A
Flores-Su?rez, LF
Flossmann, O
Flynn, D
Fonseca, JE
Foot, J
Foote, M
Forbess, L
Fujimoto, S
Fukuoka, K
Furtado, C
Furuta, S
Gaffo, AL
Gallagher, P
Gao, N
Gatenby, P
Gendi, N
Geraldes, R
Gerits, A
Gioffredi, A
Gomples, L
Gon?alves, MJ
Gondo, P
Graham, A
Grainger, R
Gray, DT
Grayson, PC
Griffiths, L
Guo, Y
Gupta, R
Gylling, M
Hajj-Ali, RA
Hammam, N
Harigai, M
Hartley, L
Haslett, J
Hassan, A
Hatemi, G
Hellmich, B
Henckaerts, L
Henes, JC
Hepburn, J
Herd, V
Hess, C
Hill, C
Hinojosa-Azaola, A
Hirahashi, J
Hirano, F
Ho?evar, A
Holle, J
Hollinger, N
Homma, S
Howard, T
Hoyles, RK
Hruskova, Z
Hutcheon, G
Ignacak, M
Igney-Oertel, A
Ikeda, K
Ikegaya, N
Jagadeesh, S
Jaquith, J
Jayne, DRW
Jewell, T
Jones, C
Joshi, A
Kalyoncu, U
Kamal?, S
Kamath, S
Lai, KS
Kaname, S
Kanchinadham, S
Karada?, ?
Karube, M
Kaszuba, M
Kaur, R
Kawakami, T
Kawashima, S
Khalidi, N
Khan, A
Kikuchi, M
Kilic, L
Kimura, M
King, MJ
Klapa, S
Klocke, R
Kobayashi, T
Kobayashi, S
Komagata, Y
Kronbichler, A
Kuczia, P
Kumar, MS
Kurosawa, M
Lamprecht, P
Langford, CA
Lanyon, P
Laversuch, C
Lee, SJ
Leoni, S
Li, J
Liang, K
Liang, P
Liao, H
Lee, LA
Luqmani, RA
Lyle, A
MacDonald, M
Mackie, SL
Madden, L
Magliano, M
Makino, H
Makol, A
Malaiya, R
Malaviya, A
Manthri, R
Maritati, F
da Silva, AM
Mason, JC
Matara, C
Matsui, K
Matteson, EL
McBride, D
McCullough, K
McGeoch, L
McLaren, J
McMillian, C
Mendiratta, N
Menon, A
Merinopoulos, D
Merkel, PA
Merkel, P
Messier, S
Micheletti, RG
Mills, K
Milman, N
Minoda, M
Minz, RW
M?ck, C
Mohammad, AJ
Moiseev, S
Moitinho, M
Molloy, E
Monach, PA
Montgomery, M
Moosig, F
Moradizadeh, M
Morgan, M
Morgan, AW
Morgan, A
Muir, A
Mukhtyar, C
M?ller, A
Muratore, F
Muso, E
Nada, R
Nakajima, H
Nakajima, T
Nakano, H
Nandagudi, A
Neumann, T
Ng, YF
Ng, KH
Nogueira, EL
Nolkha, N
Nordstr?m, D
Novikov, P
Nugaliyadde, A
O?Donnell, JL
O?Donoghue, J
O?Neill, L
O?Riordan, E
Oatley, M
Okubo, K
Oliva, E
Oshikawa, H
Ota, Y
Padoan, R
Pagnoux, C
Pan, L
Panaritis, K
Park, JK
Patel, S
Patil, P
Pazzola, G
Peall, A
Pearce, F
Pehlevan, S
Pereira, L
Pettersson, T
Pineau, CA
Piril?, L
Poglodek, B
Ponte, C
Prieto-Gonz?lez, S
Priya, SR
Purewal, B
Purschke, S
Putaala, J
Quickert, S
Quincey, V
Raghuvanshi, S
Rajasekhar, L
Ranganathan, D
Rathi, M
Rees, D
Rees, F
Renken, U
Restuccia, G
Rhee, RL
Rice, B
Robins, D
Robson, J
Rodrigues, M
Rom?o, VC
Rotar, ?
Ruediger, C
Rutgers, A
S?, AC
Saavedra, MJ
Sada, K
Sahbudin, I
Salvarani, C
Sandhu, N
Santos, E
Sato, Y
Sch?fer, VS
Schiavon, F
Schmidt, WA
Segelmark, M
Shahin, A
Sharma, A
Shotton, J
Silva, C
Singer, OG
Sivasuthan, G
Smolen, S
Solanich-Moreno, X
Boixader, LS
Song, YW
Springer, J
Sreih, AG
Srivastava, R
Stamp, LK
Stevens, R
Strbian, D
Sugino, K
Sunderk?tter, C
Suppiah, R
Suzuki, K
Szekanecz, Z
Sznajd, J
Taimen, K
Tak, PP
Takeuchi, T
Takizawa, N
Tames, L
Tan, BE
Tanaka, M
Tang, MW
Tatlisumak, T
Tesar, V
Thomas, A
Tian, X
Tokunaga, K
Tombetti, E
Tom?i?, M
Toz, B
Tsukamoto, T
Uchida, S
Unal, AU
Urban, ML
Usui, J
Vaglio, A
Venkatachalam, S
Vermaak, E
Viswanath, V
Wada, T
Wagh, S
Wallace, DJ
Walters, G
Walz, B
Wan, J
Wang, T
Wang, G
Warrington, KJ
Watts, RA
Wawrzycka-Adamczyk, K
Weeratunga, P
Weisman, MH
Wickramasinghe, S
Williams, M
Wojcik, K
Woodruff, L
Xenitidis, T
Yamada, H
Yamagata, K
Yee, C
Yoon, M
Yoshida, K
Yoshifuji, H
Ytterberg, SR
Yumura, W
Zayed, H
Zeng, X
Zhao, M
Zugaj, A
Zuk, J

Unidades de investigação

Abstract

Objectives. ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods. We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65years or >= 65years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results. A total of 1338 patients with AAV were included: 66% had disease onset at <65years of age [female 50%; mean age 48.4years (S.D. 12.6)] and 34% had disease onset at >= 65years [female 54%; mean age 73.6years (S.D. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0 .001) . Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6month VDI >= 5, compared with 7% of younger patients (P = 0 .01) . Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0 .03]. Conclusion. Within 6 months of diagnosis of AAV, patients >65years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Dados da publicação

ISSN/ISSNe:: 1462-0324, 1462-0332
Tipo:: Article
Páginas:: 617-628
DOI:: 10.1093/rheumatology/keaa215

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Keywords

age; anti-neutrophil cytoplasmic antibody–associated vasculitis; outcome

Campos de estudo

Proyectos asociados

Avaliação dos mecanismos de regulação microvascular cerebral na doença de Fabry

Investigador Principal: Elsa Irene Peixoto Azevedo Silva

Estudo Clínico Académico (Fabry) . 2020

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Nomeação institucional

Monti S,Klersy C,Montecucco C,Caporali R,Watts R,Luqmani R,Achilleos K,Adler M,Alba MA,Albert DA,Alibaz F,Allcoat P,Amano K,Amarasuriya M,Amudala NA,Andrews J,Archer AM,Arimura Y,Atukorala I,Azevedo E,Bajad S,Baldwin C,Barra LJ,Baslund B,Basu N,Baykal M,Berger C,Berglin E,Besada E,Bhardwaj M,Bischof A,Blockmans D,Blood J,Draibe JB,Brand S,Brandao M,Bruce IN,Butler A,Calabrese LH,Ferrer DC,Carette S,Carmona D,Ceunen H,Chakravarty K,Chapman PT,Chocova Z,Chung SA,Ci W,Cid MC,Clark TM,Clarkson MR,de Jesus Contreras F,Conway R,Cooke K,Vir?s XC,Cordeiro A,Costa A,Craven A,Culfear K,Daikeler T,Danda D,Das SK,Dasgupta B,De Castro AM,Dehghan N,Devassy R,Dhindsa N,Diamantopoulos AP,Direskeneli H,Dobashi H,Juan D,Durrani M,Edelsten C,Eifert J,Elhayek S,Elsideeg S,Endo T,Erden A,Erer B,Eriksson P,Erturk Z,Esp?gol G,Felicetti M,Ferraro A,Ferro JM,Fifi A,Flores LF,Flossmann O,Flynn D,Fonseca JE,Foot J,Foote M,Forbess L,Fujimoto S,Fukuoka K,Furtado C,Furuta S,Gaffo AL,Gallagher P,Gao N,Gatenby P,Gendi N,Geraldes R,Gerits A,Gioffredi A,Gomples L,Gon?alves MJ,Gondo P,Graham A,Grainger R,Gray DT,Grayson PC,Griffiths L,Guo Y,Gupta R,Gylling M,Hajj RA,Hammam N,Harigai M,Hartley L,Haslett J,Hassan A,Hatemi G,Hellmich B,Henckaerts L,Henes JC,Hepburn J,Herd V,Hess C,Hill C,Hinojosa A,Hirahashi J,Hirano F,Ho?evar A,Holle J,Hollinger N,Homma S,Howard T,Hoyles RK,Hruskova Z,Hutcheon G,Ignacak M,Igney A,Ikeda K,Ikegaya N,Jagadeesh S,Jaquith J,Jayne DRW,Jewell T,Jones C,Joshi A,Kalyoncu U,Kamal? S,Kamath S,Lai KS,Kaname S,Kanchinadham S,Karada? ?,Karube M,Kaszuba M,Kaur R,Kawakami T,Kawashima S,Khalidi N,Khan A,Kikuchi M,Kilic L,Kimura M,King MJ,Klapa S,Klocke R,Kobayashi T,Kobayashi S,Komagata Y,Kronbichler A,Kuczia P,Kumar MS,Kurosawa M,Lamprecht P,Langford CA,Lanyon P,Laversuch C,Lee SJ,Leoni S,Li J,Liang K,Liang P,Liao H,Lee LA,Luqmani RA,Lyle A,MacDonald M,Mackie SL,Madden L,Magliano M,Makino H,Makol A,Malaiya R,Malaviya A,Manthri R,Maritati F,da AM,Mason JC,Matara C,Matsui K,Matteson EL,McBride D,McCullough K,McGeoch L,McLaren J,McMillian C,Mendiratta N,Menon A,Merinopoulos D,Merkel PA,Merkel P,Messier S,Micheletti RG,Mills K,Milman N,Minoda M,Minz RW,M?ck C,Mohammad AJ,Moiseev S,Moitinho M,Molloy E,Monach PA,Montgomery M,Moosig F,Moradizadeh M,Morgan M,Morgan AW,Morgan A,Muir A,Mukhtyar C,M?ller A,Muratore F,Muso E,Nada R,Nakajima H,Nakajima T,Nakano H,Nandagudi A,Neumann T,Ng YF,Ng KH,Nogueira EL,Nolkha N,Nordstr?m D,Novikov P,Nugaliyadde A,O?Donnell JL,O?Donoghue J,O?Neill L,O?Riordan E,Oatley M,Okubo K,Oliva E,Oshikawa H,Ota Y,Padoan R,Pagnoux C,Pan L,Panaritis K,Park JK,Patel S,Patil P,Pazzola G,Peall A,Pearce F,Pehlevan S,Pereira L,Pettersson T,Pineau CA,Piril? L,Poglodek B,Ponte C,Prieto S,Priya SR,Purewal B,Purschke S,Putaala J,Quickert S,Quincey V,Raghuvanshi S,Rajasekhar L,Ranganathan D,Rathi M,Rees D,Rees F,Renken U,Restuccia G,Rhee RL,Rice B,Robins D,Robson J,Rodrigues M,Rom?o VC,Rotar ?,Ruediger C,Rutgers A,S? AC,Saavedra MJ,Sada K,Sahbudin I,Salvarani C,Sandhu N,Santos E,Sato Y,Sch?fer VS,Schiavon F,Schmidt WA,Segelmark M,Shahin A,Sharma A,Shotton J,Silva C,Singer OG,Sivasuthan G,Smolen S,Solanich X,Boixader LS,Song YW,Springer J,Sreih AG,Srivastava R,Stamp LK,Stevens R,Strbian D,Sugino K,Sunderk?tter C,Suppiah R,Suzuki K,Szekanecz Z,Sznajd J,Taimen K,Tak PP,Takeuchi T,Takizawa N,Tames L,Tan BE,Tanaka M,Tang MW,Tatlisumak T,Tesar V,Thomas A,Tian X,Tokunaga K,Tombetti E,Tom?i? M,Toz B,Tsukamoto T,Uchida S,Unal AU,Urban ML,Usui J,Vaglio A,Venkatachalam S,Vermaak E,Viswanath V,Wada T,Wagh S,Wallace DJ,Walters G,Walz B,Wan J,Wang T,Wang G,Warrington KJ,Watts RA,Wawrzycka K,Weeratunga P,Weisman MH,Wickramasinghe S,Williams M,Wojcik K,Woodruff L,Xenitidis T,Yamada H,Yamagata K,Yee C,Yoon M,Yoshida K,Yoshifuji H,Ytterberg SR,Yumura W,Zayed H,Zeng X,Zhao M,Zugaj A,Zuk J. Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes. RHEUMATOLOGY. 2021. 60. (2):p. 617-628. IF:7,046. (1).