The effects of trazodone on human cognition: a systematic review

Autores da FMUP
Participantes de fora da FMUP
- Gonçalo, AMG
Unidades de investigação
Abstract
Trazodone is a widely used antidepressant that is also useful in the control of agitation and insomnia in Alzheimers disease. This drug is now recognized as having a new mechanism of action, an effect on the unfolded protein response (UPR) pathway, restoring protein translation and slowing neurodegenerative progression in mice. This mechanism may have a role in dementia-modifying treatment.?To explore the effects of trazodone on human cognition and to search for clinical evidence of its putative benefits in human neurodegenerative diseases, a systematic review was conducted for studies that evaluated the effect of a minimum dose of 25?mg of trazodone daily, for at least 1?week, on cognition in adult humans. The search was run in MEDLINE, Web of Science, and CENTRAL from the Cochrane databases, yielding a total of 16 studies after selection. Overall, seven studies showed no effect of trazodone on cognition, five showed a beneficial effect by improving or reducing cognitive decline, and four evidenced impaired cognitive function. Our analysis highlights the possibility of a dose-independent dual effect of trazodone on human cognition, with acute utilization associated with impaired cognitive function and long-term use with preventing cognitive deterioration. There was no clinical evidence that trazodone could be used as a specific treatment of neurodegenerative diseases. Future studies should explore the role of trazodone in the UPR pathway and the implications in neurodegenerative diseases in humans. ? 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Dados da publicação
- ISSN/ISSNe:
- 0031-6970, 1432-1041
- Tipo:
- Article
- Páginas:
- 1623-1637
- Link para outro recurso:
- www.scopus.com
European Journal of Clinical Pharmacology Springer Verlag
Citações Recebidas na Web of Science: 8
Citações Recebidas na Scopus: 12
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Keywords
- All cognitive disorders; dementia; Alzheimer's disease; Memory; Executive function; Trazodone
Proyectos asociados
Ongoing Clinical Trials with Monoclonal Antibodies in Schizophrenia
Investigador Principal: Maria Augusta Vieira Coelho
Estudo Clínico Académico . 2020
Citar a publicação
Gonçalo A,Coelho M. The effects of trazodone on human cognition: a systematic review. Eur. J. Clin. Pharmacol. 2021. 77. (11):p. 1623-1637. IF:3,064. (3).