Modified glasgow prognostic score predicts survival among advanced non-small cell lung carcinoma patients treated with anti-PD1 agents

Autores da FMUP

• Hélder Novais E Bastos

  Autor

Participantes de fora da FMUP

• Freitas, C.
• Jacob, M.
• Nuno Tavares
• Cruz Martins, N.
• Moura, M.
• Ara?jo, D.
• Vanessa Santos
• Oliveira Fernandes, M.
• Adriana Magalh?es
• Espanhol, V.
• Queiroga, H.

Unidades de investigação

• Medicina

Abstract

Immune checkpoint inhibitors were approved for advanced nonsmall cell lung cancer (NSCLC) treatment. Despite improved survival, not all patients benefit from these agents. Here, the prognostic impact of pretreatment modified Glasgow Prognostic Score (mGPS) and neutrophil-to-lymphocyte ratio (NLR) was assessed. From 77 patients included, 83.2% received at least one prior systemic therapy. Immune-related adverse events (irAE) occurred in 20 patients. A lower mGPS was associated with higher median overall survival (OS), and a lower Eastern Cooperative Oncology Group (ECOG), irAE and fewer metastatic sites with better survival. A trend towards greater OS and progression-free survival (PFS) was stated among patients with NLR 2 with worse OS and irAE with better survival. Pretreatment mGPS seems to be useful for predicting survival among advanced NSCLC patients treated with anti-programmed cell death 1 drugs, with ECOG performance status, irAE occurrence, and number of metastatic sites acting as survival predictors.

Keywords

• anti-PD1 agents; immune checkpoint inhibitors; immunotherapy; modified Glasgow Prognostic Score; nonsmall cell lung carcinoma