Portal de investigação
Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Vieira, ACR
- Ferra, JRM
- De Carvalho, JSV
- Melo, N
- Mota, PC
- Pereira, JM
- Moura, CS
Unidades de investigação
Abstract
Pleuroparenchymal fibroelastosis (PPFE) is a rare and recently described distinct pattern of lung apical fibrosis involving the upper lobe parenchyma and pleural dome. PPFE has definable and reproducible clinical, radiological and histopathological criteria, which allowed its classification as an independent interstitial lung disease. Several factors have been associated with PPFE, such as chemotherapy, especially with alkylating agents. The authors present a case of a 34-year-old female with previous history of Hodgkin lymphoma treated with first line chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine). The patient had no other known comorbidities or relevant exposure to lung irritants. A total of 2 years after completing cancer treatment, the patient developed clinical and radiological features of PPFE. Given their previous history of malignancy, a biopsy of the lesion was obtained, which confirmed the diagnosis of PPFE. The authors present this case to raise awareness of this disease and to demonstrate that PPFE can develop months to years following chemotherapy treatment. Moreover, to date, none of these chemotherapy agents have been associated with the development of PPFE.
Dados da publicação
- ISSN/ISSNe:
- 2049-9450, 2049-9469
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
Molecular and Clinical Oncology Spandidos Publications UK
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 2
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Keywords
- pleuroparenchymal fibroelastosis; chemotherapy; doxorubicin; bleomycin; vinblastine; dacarbazine
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Citar a publicação
Vieira A,Ferra JRM,De Carvalho JSV,Melo N,Mota PC,Bastos H,Pereira JM,Moura CS,Morais A. Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report. Mol. Clin. Oncol. 2022. 16. (3):71.
