Cognitive impairment and markers of optical neurodegeneration in early multiple sclerosis

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Inês Passos E Castro Neto Ferreira

    Autor

  • Luís Manuel Rebelo Ruano

    Autor

Participantes de fora da FMUP

  • Silva, R
  • Coelho, P
  • Seabra, M
  • Laranjinha, I
  • Vieira, D
  • Costa, O
  • Jesus, J
  • Fonseca, AC
  • Costa, S
  • Lemos, J
  • Sousa, C
  • Vale, J
  • Sá, MJ

Unidades de investigação

Abstract

Introduction Cognitive impairment and retinal atrophy have been proposed as two potential markers of neurodegeneration in multiple sclerosis (MS). We aimed at assessing the relation between peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell layer (mGCL) atrophy and cognitive performance in early MS. Methods This is a multicenter cross-sectional study on patients with early MS (clinically isolated syndrome and relapsing-remitting MS), with an EDSS score <= 3.0. Patients with previous optic neuritis, other ocular diseases, psychiatric illness, or recent relapse were excluded. All patients underwent standardized optical coherence tomography (OCT) and neuropsychological evaluation with validated tests for MS patients. Cognitive impairment was defined as having two cognitive tasks below age- and education-adjusted norms. Results We recruited 52 patients with early MS, with an average age of 37 years (SD =10.5), an average disease duration of 3.69 years (SD =2.3), and a median EDSS of 1.0 (IQR = 0.5). In this sample, 15/52 patients presented cognitive impairment. Regarding OCT measurements, 7/52 patients had an average pRNFL below the 5th percentile and 2/52 had an average mGCL below the 5th percentile. The average pRNFL thickness was comparable in cognitively impaired and cognitively preserved patients (100.3 mu m vs 103.1 mu m, p = 0.52); the average mGCL thickness had also similar values between groups (50.5 mu m vs 53 mu m, p = 0.38). Conclusions Cognitive impairment was frequent in our sample of early MS. However, no association with reduced pRNFL or mGCL thickness was found. When compared to OCT, cognitive assessment could provide an earlier marker of neurodegeneration in MS.

Dados da publicação

ISSN/ISSNe:
1590-1874, 1590-3478

Neurological Sciences  Springer-Verlag Italia Srl

Tipo:
Article
Páginas:
4381-4386
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 2

Citações Recebidas na Scopus: 6

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Keywords

  • Multiple sclerosis; Cognitive impairment; Optical coherence tomography; Neurodegeneration

Financiamento

Proyectos asociados

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Estudo Clínico Académico (Glomerulonephritis) . 2020

New insights into immune mechanisms in idiopathic membranous nephropathy

Investigador Principal: Inês Passos e Castro Neto Ferreira

Estudo Clínico Académico (idiopathic) . 2020

Podocitopatia lúpica: uma visão geral sobre esta nova variante histológica

Investigador Principal: Inês Passos e Castro Neto Ferreira

Estudo Clínico Académico . 2021

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