Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis
Autores da FMUP
Participantes de fora da FMUP
- Coelho, M
- Squizzato, A
- Cassina, N
- Marino, F
- Cosentino, M
Unidades de investigação
Abstract
The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible beneficial effect of beta-blocker on overall survival in lung cancer patients. Medline and Embase databases were searched from inception until 1 May 2018 to identify published studies that assessed the effect beta-blocker use on overall survival in lung cancer patients. Risk of bias was evaluated by Newcastle-Ottawa scale. Hazard ratios and 95% confidence intervals for overall survival were estimated using a random-effects model. Of 920 studies, seven (all retrospective and observational, six cohort and one case-control), including 7448 patients, met the inclusion criteria. Beta-blocker users with lung cancer had no increased overall survival compared to non-users (hazard ratio = 1.00; 95% confidence interval = 0.91-1.10; I-2= 45%). Similarly, beta-blocker users with non-small cell lung cancer had no increased overall survival compared to beta-blocker non-users (hazard ratio = 0.96; 95% confidence interval = 0.80-1.17; I-2= 56%). Our findings do not suggest an overall survival advantage in patients with lung cancer using beta-blocker therapy when compared to non-users. Further prospective cohort studies, designed to overcome the intrinsic limitations of retrospective observational studies are warranted to definitively clarify any possible beneficial effect of beta-blockers on lung cancer overall survival.
Dados da publicação
- ISSN/ISSNe:
- 1473-5709, 0959-8278
- Tipo:
- Review
- Páginas:
- 306-314
EUROPEAN JOURNAL OF CANCER PREVENTION Lippincott Williams and Wilkins Ltd.
Citações Recebidas na Web of Science: 7
Documentos
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Filiações
Keywords
- beta-blockers; lung cancer; meta-analysis; overall survival
Proyectos asociados
Ensino-aprendizagem e perfil psicológico dos estudantes de medicina na pandemia Covid-19.
Investigador Principal: Laura Virginia Pereira Teixeira Ribeiro
Estudo Observacional Académico (PerfilPsic) . 2020
Citar a publicação
Coelho M,Squizzato A,Cassina N,Marino F,Ribeiro L,Cosentino M. Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis. Eur. J. Cancer Prev. 2020. 29(4):p. 306-314. IF:2,497. (4).