Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Autores da FMUP

• Marta Borges Canha

  Autor

• João Sérgio De Lima Soares Neves

  Autor

• Fernando Miguel Da Silva Mendonça

  Autor

• Carla Susana Fernandes Da Costa De Araújo

  Autor

• Vanessa Alexandra Guerreiro Gonçalves

  Autor

• Jorge Manuel P. Pires Pedro

  Autor

• Eva Lau Gouveia

  Autor

• Selma Maria Barbosa Souto

  Autor

• Paula Isabel Marques Simões De Freitas

  Autor

• Davide Maurício Costa Carvalho

  Autor

Participantes de fora da FMUP

• Silva, MM
• Cabral, PM
• Lourenço, R
• Meira, P
• Salazar, D
• Ferreira, MJ
• Barkoudah, E
• Sande, A
• Preto, J

Unidades de investigação

• Cirurgia e Fisiologia

• Ginecologia-Obstetrícia e Pediatria

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Medicina

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Background Obesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain. Aim To evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery in patients with morbid obesity. Methods Retrospective longitudinal study in patients with morbid obesity followed in our center between January 2010 and July 2018. Patients were excluded if they had diabetes at baseline or missing data on the needed parameters. We evaluated baseline Homeostatic Model Assessment of IR, Homeostatic Model Assessment of beta-cell function (HOMA-beta), Quantitative Insulin Sensitivity Check Index, and Matsuda and DeFronzo index, and TBWL% at years 1 to 4. Linear regression models were used to evaluate the association of indexes of insulin resistance with TBWL% (unadjusted and adjusted for age, sex, BMI, and type of surgery). Results There were 1,561 patients included in this analysis. HOMA-beta was negatively associated with TBWL% at second, third, and fourth years post-surgery (beta = -1.04 [-1.82 to -0.26], p<0.01; beta = -1.16 [-2.13 to -0.19], p=0.02; beta = -1.29 [-2.64 to 0.06], p=0.061, respectively). This was not observed in the first year post-surgery nor for the other indexes. Glycemia at baseline was positively associated to EWL% at second and third years post-surgery. Conclusion beta-cell function at baseline seems to be associated to long-term weight loss, explicitly after the first year post bariatric surgery. This might be a helpful predictor of weight loss in clinical practice.

Keywords

• beta cell function; insulin resistance; bariatric surgery; morbid obesity; weight loss