Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Data de publicação: 01/06/2021 Data Ahead of Print: 01/05/2021

Autores da FMUP

José Adelino Lobarinhas Barbosa

Autor
André Manuel Costa Pinho

Autor
Clara Maria Pires Costa De Bastos Monteiro

Autor

Participantes de fora da FMUP

Gossage, JA
Hodson, J
Vohra, RS
Alderson, D
Bundred, J
Evans, RPT
Griffiths, EA
Jefferies, B
Kamarajah, SK
Nepogodiev, D
Siaw-Acheampong, K
Wanigasooriya, K
Whitehouse, T
Gjata, A
Moreno, JI
Takeda, FR
Kidane, B
Guevara, CR
Harustiak, T
Bekele, A
Kechagias, A
Gockel, I
Kennedy, A
Da Roit, A
Bagajevas, A
Azagra, JS
Mahendran, HA
Mejía-Fernández, L
Wijnhoven, BPL
El Kafsi, J
Sayyed, RH
Sousa, M
Sampaio, AS
Negoi, I
Blanco, R
Wallner, B
Schneider, PM
Hsu, PK
Isik, A
Gananadha, S
Wills, V
Devadas, M
Duong, C
Talbot, M
Hii, MW
Jacobs, R
Andreollo, NA
Johnston, B
Darling, G
Isaza-Restrepo, A
Rosero, G
Arias-Amézquita, F
Raptis, D
Gaedcke, J
Reim, D
Izbicki, J
Egberts, JH
Dikinis, S
Kjaer, DW
Larsen, MH
Achiam, MP
Saarnio, J
Theodorou, D
Liakakos, T
Korkolis, DP
Robb, WB
Collins, C
Murphy, T
Reynolds, J
Tonini, V
Migliore, M
Bonavina, L
Valmasoni, M
Bardini, R
Weindelmayer, J
Terashima, M
White, RE
Alghunaim, E
Elhadi, M
Leon-Takahashi, AM
Medina-Franco, H
Lau, PC
Okonta, KE
Heisterkamp, J
Rosman, C
van Hillegersberg, R
Beban, G
Babor, R
Gordon, A
Rossaak, JI
Pal, KMI
Qureshi, AU
Naqi, SA
Syed, AA
Vicente, CS
Leite, J
Freire, J
Casaca, R
Costa, RCT
Scurtu, RR
Mogoanta, SS
Bolca, C
Constantinoiu, S
Sekhniaidze, D
Bjelovic, M
So, JBY
Gacevski, G
Loureiro, C
Pera, M
Bianchi, A
Moreno, GM
Fernández, JM
Carrera, MST
Vallve-Bernal, M
Pascual, MAC
Elmahi, S
Halldestam, I
Hedberg, J
Mönig, S
Gutknecht, S
Tez, M
Guner, A
Tirnaksiz, MB
Colak, E
Sevinç, B
Hindmarsh, A
Khan, I
Khoo, D
Byrom, R
Gokhale, J
Wilkerson, P
Jain, P
Chan, D
Robertson, K
Iftikhar, S
Skipworth, R
Forshaw, M
Higgs, S
Gossage, J
Nijjar, R
Viswanath, YKS
Turner, P
Dexter, S
Boddy, A
Allum, WH
Oglesby, S
Cheong, E
Beardsmore, D
Vohra, R
Maynard, N
Berrisford, R
Mercer, S
Puigt, S
Melhadot, R
Kelty, C
Underwood, T
Dawas, K
Lewis, W
Al-Bahrani, A
Bryce, G
Thomas, M
Arndt, AT
Palazzo, F
Meguid, RA
Fergusson, J
Beenen, E
Mosse, C
Salim, J
Cheah, S
Wright, T
Cerdeira, MP
McQuillan, P
Richardson, M
Liem, H
Spillane, J
Yacob, M
Albadawi, F
Thorpe, T
Dingle, A
Cabalag, C
Loi, K
Fisher, OM
Ward, S
Read, M
Johnson, M
Bassari, R
Bui, H
Cecconello, I
Sallum, RAA
da Rocha, JRM
Lopes, LR
Tercioti, V
Coelho, JD
Ferrer, JAP
Buduhan, G
Tan, L
Srinathan, S
Shea, P
Yeung, J
Allison, F
Carroll, P
Vargas-Barato, F
Gonzalez, F
Ortega, J
Nino-Torres, L
Beltrán-García, TC
Castilla, L
Pineda, M
Bastidas, A
Gómez-Mayorga, J
Cortes, N
Cetares, C
Caceres, S
Duarte, S
Pazdro, A
Snajdauf, M
Faltova, H
Sevcikova, M
Mortensen, PB
Katballe, N
Ingemann, T
Morten, B
Kruhlikava, I
Ainswort, AP
Stilling, NM
Eckardt, J
Holm, J
Thorsteinsson, M
Siemsen, M
Brandt, B
Nega, B
Teferra, E
Tizazu, A
Kauppila, JH
Koivukangas, V
Meriläinen, S
Gruetzmann, R
Krautz, C
Weber, G
Golcher, H
Emons, G
Azizian, A
Ebeling, M
Niebisch, S
Kreuser, N
Albanese, G
Hesse, J
Volovnik, L
Boecher, U
Reeh, M
Triantafyllou, S
Schizas, D
Michalinos, A
Mpali, E
Mpoura, M
Charalabopoulos, A
Manatakis, DK
Balalis, D
Bolger, J
Baban, C
Mastrosimone, A
McAnena, O
Quinn, A
Súilleabháin, CBO
Hennessy, MM
Ivanovski, I
Khizer, H
Ravi, N
Donlon, N
Cervellera, M
Vaccari, S
Bianchini, S
Sartarelli, L
Asti, E
Bernardi, D
Merigliano, S
Provenzano, L
Scarpa, M
Saadeh, L
Salmaso, B
De Manzoni, G
Giacopuzzi, S
La Mendola, R
De Pasqual, CA
Tsubosa, Y
Niihara, M
Irino, T
Makuuchi, R
Ishii, K
Mwachiro, M
Fekadu, A
Odera, A
Mwachiro, E
AlShehab, D
Ahmed, HA
Shebani, AO
Elhadi, A
Elnagar, FA
Elnagar, HF
Makkai-Popa, ST
Wong, LF
Tan, YR
Thannimalai, S
Ho, CA
Pang, WS
Tan, JH
Basave, HNL
Cortes-Gonzalez, R
Lagarde, SM
van Lanschot, JJB
Cords, C
Jansen, WA
Martijnse, I
Matthijsen, R
Bouwense, S
Klarenbeek, B
Verstegen, M
van Workum, F
Ruurda, JP
van der Sluis, PC
de Maat, M
Evenett, N
Johnston, P
Patel, R
MacCormick, A
Young, M
Smith, B
Ekwunife, C
Memon, AH
Shaikh, K
Wajid, A
Khalil, N
Haris, M
Mirza, ZU
Qudus, SBA
Sarwar, MZ
Shehzadi, A
Raza, A
Jhanzaib, MH
Farmanali, J
Zakir, Z
Shakeel, O
Nasir, I
Khattak, S
Baig, M
Noor, MA
Ahmed, HH
Naeem, A
da Silva, R
Bernardes, A
Campos, JC
Matos, H
Braga, T
Ramos, P
Cabral, F
Gomes, MP
Martins, PC
Correia, AM
Videira, JF
Drasovean, R
Apostu, R
Ciuce, C
Paitici, S
Racu, AE
Obleaga, CV
Beuran, M
Stoica, B
Ciubotaru, C
Negoita, V
Cordos, I
Birla, RD
Predescu, D
Hoara, PA
Tomsa, R
Shneider, V
Agasiev, M
Ganjara, I
Gunjic, D
Veselinovic, M
Babic, T
Chin, TS
Shabbir, A
Kim, G
Crnjac, A
Samo, H
Del Val, ID
Leturio, S
Ramón, JM
Dal Cero, M
Rifá, S
Rico, M
Pomar, AP
Corcoles, JAM
Miravalles, JLR
Pais, SA
Turienzo, SA
Alvarezt, LS
Alvarez, LS
Campos, PV
Rendo, AG
Garcia, SS
Santos, EPG
Martínez, ET
Fernández, DM
Magadán, AC
Concepción, MV
Díaz, LC
Rosat, RA
Pérez, SLE
Bailón, CM
Tinoco, CC
Bhojwani, EC
Sánchez, DP
Ahmed, ME
Dzhendov, T
Lindberg, F
Rutegård, M
Sundbom, M
Mickael, C
Colucci, N
Schnider, A
Er, S
Kurnaz, E
Turkyilmaz, S
Turkyilmaz, A
Yildirim, R
Baki, BE
Akkapulu, N
Karahan, O
Damburaci, N
Hardwickt, R
Safranek, P
Sujendran, V
Bennett, J
Afzal, Z
Shrotri, M
Chan, B
Exarchou, K
Gilbert, T
Amalesh, T
Mukherjee, D
Mukherjee, S
Wiggins, TH
Kennedy, R
McCain, S
Harris, A
Dobson, G
Davies, N
Wilson, I
Mayo, D
Bennett, D
Young, R
Manby, P
Blencowe, N
Schiller, M
Byrne, B
Mitton, D
Wong, V
Elshaer, A
Cowen, M
Menon, V
Tan, LC
McLaughlin, E
Koshy, R
Sharp, C
Brewer, H
Das, N
Cox, M
Al Khyatt, W
Worku, D
Iqbal, R
Walls, L
McGregor, R
Fullarton, G
Macdonald, A
MacKay, C
Craig, C
Dwerryhouse, S
Hornby, S
Jaunoo, S
Wadley, M
Baker, C
Saad, M
Kelly, M
Davies, A
Di Maggio, F
McKay, S
Mistry, P
Singhal, R
Tucker, O
Kapoulas, S
Powell-Brett, S
Davis, P
Bromley, G
Watson, L
Verma, R
Ward, J
Shetty, V
Ball, C
Pursnani, K
Sarela, A
Sue, LH
Mehta, S
Hayden, J
To, N
Palser, T
Hunter, D
Supramaniam, K
Butt, Z
Ahmed, A
Kumar, S
Chaudry, A
Moussa, O
Kordzadeh, A
Lorenzi, B
Wilson, M
Patil, P
Noaman, I
Willem, J
Bouras, G
Evans, R
Singh, M
Warrilow, H
Ahmad, A
Tewari, N
Yanni, F
Couch, J
Theophilidou, E
Reilly, JJ
Singh, P
van Boxel, G
Akbari, K
Zanotti, D
Sgromo, B
Sanders, G
Wheatley, T
Ariyarathenam, A
Reece-Smith, A
Humphreys, L
Choh, C
Carter, N
Knight, B
Pucher, P
Athanasiou, A
Mohamed, I
Tan, B
Abdulrahman, M
Vickers, J
Akhtar, K
Chaparala, R
Brown, R
Alasmar, MMA
Ackroyd, R
Patel, K
Tamhankar, A
Wyman, A
Walker, R
Grace, B
Abbassi, N
Slim, N
Ioannidi, L
Blackshaw, G
Havard, T
Escofet, X
Powell, A
Owera, A
Rashid, F
Jambulingam, P
Padickakudi, J
Ben-Younes, H
Mccormack, K
Makey, IA
Karush, MK
Seder, CW
Liptay, MJ
Chmielewski, G
Rosato, EL
Berger, AC
Zheng, R
Okolo, E
Singh, A
Scott, CD
Weyant, MJ
Mitchell, JD
Oesophago-Gastric Anastomotic

Unidades de investigação

Abstract

Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method: This international multi-center prospective study across 137 hospitals in 41 countries included patients who underwent an esophagectomy for esophageal cancer, with 90-day follow-up. The main explanatory variable was country income, defined according to the World Bank Data classification. The primary outcome was 90-day postoperative mortality, and secondary outcomes were composite leaks (anastomotic leak or conduit necrosis) and major complications (Clavien-Dindo Grade III-V). Multivariable generalized estimating equation models were used to produce adjusted odds ratios (ORs) and 95% confidence intervals (CI95%). Results: Between April 2018 to December 2018, 2247 patients were included. Patients from HIC were more significantly older, with higher ASA grade, and more advanced tumors. Patients from LMIC had almost three-fold increase in 90-day mortality, compared to HIC (9.4% vs 3.7%, p < 0.001). On adjusted analysis, LMIC were independently associated with higher 90-day mortality (OR: 2.31, CI95%: 1.17-4.55, p = 0.015). However, LMIC were not independently associated with higher rates of anastomotic leaks (OR: 1.06, CI95%: 0.57-1.99, p = 0.9) or major complications (OR: 0.85, CI95%: 0.54-1.32, p = 0.5), compared to HIC. Conclusion: Resections in LMIC were independently associated with higher 90-day postoperative mortality, likely reflecting a failure to rescue of these patients following esophagectomy, despite similar composite anastomotic leaks and major complication rates to HIC. These findings warrant further research, to identify potential issues and solutions to improve global outcomes following esophagectomy for cancer. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Dados da publicação

ISSN/ISSNe:: 1532-2157, 0748-7983
Tipo:: Article
Páginas:: 1481-1488
DOI:: 10.1016/j.ejso.2020.12.006
Link para outro recurso:: www.scopus.com

Documentos

Não há documentos

Métricas

Filiações

Keywords

Global surgery; Esophagectomy; Anastomotic leak; Postoperative mortality

Campos de estudo

Proyectos asociados

Impact of neoadjuvant chemotherapy in the treatment of patients with gastric cancer

Investigador Principal: José Adelino Lobarinhas Barbosa

Estudo Clínico Académico (Chemotherapy) . 2020

Health related Quality of Life six years after bariatric surgery: factors influencing outcome

Investigador Principal: André Manuel Costa Pinho

Estudo Clínico Académico . 2020

Qualidade de vida pós-cirurgica e resultados no tratamento da acalásia

Investigador Principal: José Adelino Lobarinhas Barbosa

Estudo Clínico Académico . 2020

Citar a publicação

Nomeação institucional

Gossage JA,Hodson J,Vohra RS,Alderson D,Bundred J,Evans RPT,Griffiths EA,Jefferies B,Kamarajah SK,Nepogodiev D,Siaw K,Wanigasooriya K,Whitehouse T,Gjata A,Moreno JI,Takeda FR,Kidane B,Guevara CR,Harustiak T,Bekele A,Kechagias A,Gockel I,Kennedy A,Da A,Bagajevas A,Azagra JS,Mahendran HA,Mejía L,Wijnhoven BPL,El Kafsi J,Sayyed RH,Sousa M,Sampaio AS,Negoi I,Blanco R,Wallner B,Schneider PM,Hsu PK,Isik A,Gananadha S,Wills V,Devadas M,Duong C,Talbot M,Hii MW,Jacobs R,Andreollo NA,Johnston B,Darling G,Isaza A,Rosero G,Arias F,Raptis D,Gaedcke J,Reim D,Izbicki J,Egberts JH,Dikinis S,Kjaer DW,Larsen MH,Achiam MP,Saarnio J,Theodorou D,Liakakos T,Korkolis DP,Robb WB,Collins C,Murphy T,Reynolds J,Tonini V,Migliore M,Bonavina L,Valmasoni M,Bardini R,Weindelmayer J,Terashima M,White RE,Alghunaim E,Elhadi M,Leon AM,Medina H,Lau PC,Okonta KE,Heisterkamp J,Rosman C,van R,Beban G,Babor R,Gordon A,Rossaak JI,Pal K,Qureshi AU,Naqi SA,Syed AA,Barbosa J,Vicente CS,Leite J,Freire J,Casaca R,Costa RCT,Scurtu RR,Mogoanta SS,Bolca C,Constantinoiu S,Sekhniaidze D,Bjelovic M,JBY,Gacevski G,Loureiro C,Pera M,Bianchi A,Moreno GM,Fernández JM,Carrera MST,Vallve M,Pascual M,Elmahi S,Halldestam I,Hedberg J,Mönig S,Gutknecht S,Tez M,Guner A,Tirnaksiz MB,Colak E,Sevinç B,Hindmarsh A,Khan I,Khoo D,Byrom R,Gokhale J,Wilkerson P,Jain P,Chan D,Robertson K,Iftikhar S,Skipworth R,Forshaw M,Higgs S,Gossage J,Nijjar R,Viswanath YKS,Turner P,Dexter S,Boddy A,Allum WH,Oglesby S,Cheong E,Beardsmore D,Vohra R,Maynard N,Berrisford R,Mercer S,Puigt S,Melhadot R,Kelty C,Underwood T,Dawas K,Lewis W,Al A,Bryce G,Thomas M,Arndt AT,Palazzo F,Meguid RA,Fergusson J,Beenen E,Mosse C,Salim J,Cheah S,Wright T,Cerdeira MP,McQuillan P,Richardson M,Liem H,Spillane J,Yacob M,Albadawi F,Thorpe T,Dingle A,Cabalag C,Loi K,Fisher OM,Ward S,Read M,Johnson M,Bassari R,Bui H,Cecconello I,Sallum R,da JRM,Lopes LR,Tercioti V,Coelho JD,Ferrer J,Buduhan G,Tan L,Srinathan S,Shea P,Yeung J,Allison F,Carroll P,Vargas F,Gonzalez F,Ortega J,Nino L,Beltrán TC,Castilla L,Pineda M,Bastidas A,Gómez J,Cortes N,Cetares C,Caceres S,Duarte S,Pazdro A,Snajdauf M,Faltova H,Sevcikova M,Mortensen PB,Katballe N,Ingemann T,Morten B,Kruhlikava I,Ainswort AP,Stilling NM,Eckardt J,Holm J,Thorsteinsson M,Siemsen M,Brandt B,Nega B,Teferra E,Tizazu A,Kauppila JH,Koivukangas V,Meriläinen S,Gruetzmann R,Krautz C,Weber G,Golcher H,Emons G,Azizian A,Ebeling M,Niebisch S,Kreuser N,Albanese G,Hesse J,Volovnik L,Boecher U,Reeh M,Triantafyllou S,Schizas D,Michalinos A,Mpali E,Mpoura M,Charalabopoulos A,Manatakis DK,Balalis D,Bolger J,Baban C,Mastrosimone A,McAnena O,Quinn A,Súilleabháin C,Hennessy MM,Ivanovski I,Khizer H,Ravi N,Donlon N,Cervellera M,Vaccari S,Bianchini S,Sartarelli L,Asti E,Bernardi D,Merigliano S,Provenzano L,Scarpa M,Saadeh L,Salmaso B,De Manzoni G,Giacopuzzi S,La Mendola R,De Pasqual CA,Tsubosa Y,Niihara M,Irino T,Makuuchi R,Ishii K,Mwachiro M,Fekadu A,Odera A,Mwachiro E,AlShehab D,Ahmed HA,Shebani AO,Elhadi A,Elnagar FA,Elnagar HF,Makkai ST,Wong LF,Tan YR,Thannimalai S,Ho CA,Pang WS,Tan JH,Basave HNL,Cortes R,Lagarde SM,van JJB,Cords C,Jansen WA,Martijnse I,Matthijsen R,Bouwense S,Klarenbeek B,Verstegen M,van F,Ruurda JP,van der Sluis PC,de Maat M,Evenett N,Johnston P,Patel R,MacCormick A,Young M,Smith B,Ekwunife C,Memon AH,Shaikh K,Wajid A,Khalil N,Haris M,Mirza ZU,Qudus S,Sarwar MZ,Shehzadi A,Raza A,Jhanzaib MH,Farmanali J,Zakir Z,Shakeel O,Nasir I,Khattak S,Baig M,Noor MA,Ahmed HH,Naeem A,Pinho AC,da R,Bernardes A,Campos JC,Matos H,Braga T,Monteiro C,Ramos P,Cabral F,Gomes MP,Martins PC,Correia AM,Videira JF,Drasovean R,Apostu R,Ciuce C,Paitici S,Racu AE,Obleaga CV,Beuran M,Stoica B,Ciubotaru C,Negoita V,Cordos I,Birla RD,Predescu D,Hoara PA,Tomsa R,Shneider V,Agasiev M,Ganjara I,Gunjic D,Veselinovic M,Babic T,Chin TS,Shabbir A,Kim G,Crnjac A,Samo H,Del Val ID,Leturio S,Ramón JM,Dal M,Rifá S,Rico M,Pomar AP,Corcoles J,Miravalles JLR,Pais SA,Turienzo SA,Alvarezt LS,Alvarez LS,Campos PV,Rendo AG,Garcia SS,Santos E,Martínez ET,Fernández DM,Magadán AC,Concepción MV,Díaz LC,Rosat RA,Pérez S,Bailón CM,Tinoco CC,Bhojwani EC,Sánchez DP,Ahmed ME,Dzhendov T,Lindberg F,Rutegård M,Sundbom M,Mickael C,Colucci N,Schnider A,Er S,Kurnaz E,Turkyilmaz S,Turkyilmaz A,Yildirim R,Baki BE,Akkapulu N,Karahan O,Damburaci N,Hardwickt R,Safranek P,Sujendran V,Bennett J,Afzal Z,Shrotri M,Chan B,Exarchou K,Gilbert T,Amalesh T,Mukherjee D,Mukherjee S,Wiggins TH,Kennedy R,McCain S,Harris A,Dobson G,Davies N,Wilson I,Mayo D,Bennett D,Young R,Manby P,Blencowe N,Schiller M,Byrne B,Mitton D,Wong V,Elshaer A,Cowen M,Menon V,Tan LC,McLaughlin E,Koshy R,Sharp C,Brewer H,Das N,Cox M,Al Khyatt W,Worku D,Iqbal R,Walls L,McGregor R,Fullarton G,Macdonald A,MacKay C,Craig C,Dwerryhouse S,Hornby S,Jaunoo S,Wadley M,Baker C,Saad M,Kelly M,Davies A,Di F,McKay S,Mistry P,Singhal R,Tucker O,Kapoulas S,Powell S,Davis P,Bromley G,Watson L,Verma R,Ward J,Shetty V,Ball C,Pursnani K,Sarela A,Sue LH,Mehta S,Hayden J,To N,Palser T,Hunter D,Supramaniam K,Butt Z,Ahmed A,Kumar S,Chaudry A,Moussa O,Kordzadeh A,Lorenzi B,Wilson M,Patil P,Noaman I,Willem J,Bouras G,Evans R,Singh M,Warrilow H,Ahmad A,Tewari N,Yanni F,Couch J,Theophilidou E,Reilly JJ,Singh P,van G,Akbari K,Zanotti D,Sgromo B,Sanders G,Wheatley T,Ariyarathenam A,Reece A,Humphreys L,Choh C,Carter N,Knight B,Pucher P,Athanasiou A,Mohamed I,Tan B,Abdulrahman M,Vickers J,Akhtar K,Chaparala R,Brown R,Alasmar M,Ackroyd R,Patel K,Tamhankar A,Wyman A,Walker R,Grace B,Abbassi N,Slim N,Ioannidi L,Blackshaw G,Havard T,Escofet X,Powell A,Owera A,Rashid F,Jambulingam P,Padickakudi J,Ben H,Mccormack K,Makey IA,Karush MK,Seder CW,Liptay MJ,Chmielewski G,Rosato EL,Berger AC,Zheng R,Okolo E,Singh A,Scott CD,Weyant MJ,Mitchell JD,Oesophago A. Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study. Eur. J. Surg. Oncol. 2021. 47. (6):p. 1481-1488. IF:4,037. (1).

Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Autores da FMUP

José Adelino Lobarinhas Barbosa

André Manuel Costa Pinho

Clara Maria Pires Costa De Bastos Monteiro

Participantes de fora da FMUP

Unidades de investigação

Biomedicina

Cirurgia e Fisiologia

Abstract

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Impact of neoadjuvant chemotherapy in the treatment of patients with gastric cancer

Health related Quality of Life six years after bariatric surgery: factors influencing outcome

Qualidade de vida pós-cirurgica e resultados no tratamento da acalásia

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Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Autores da FMUP

José Adelino Lobarinhas Barbosa

André Manuel Costa Pinho

Clara Maria Pires Costa De Bastos Monteiro

Participantes de fora da FMUP

Unidades de investigação

Biomedicina

Cirurgia e Fisiologia

Abstract

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Impact of neoadjuvant chemotherapy in the treatment of patients with gastric cancer

Health related Quality of Life six years after bariatric surgery: factors influencing outcome

Qualidade de vida pós-cirurgica e resultados no tratamento da acalásia

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