Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • José Adelino Lobarinhas Barbosa

    Autor

  • André Manuel Costa Pinho

    Autor

  • Clara Maria Pires Costa De Bastos Monteiro

    Autor

Participantes de fora da FMUP

  • Gossage, JA
  • Hodson, J
  • Vohra, RS
  • Alderson, D
  • Bundred, J
  • Evans, RPT
  • Griffiths, EA
  • Jefferies, B
  • Kamarajah, SK
  • Nepogodiev, D
  • Siaw-Acheampong, K
  • Wanigasooriya, K
  • Whitehouse, T
  • Gjata, A
  • Moreno, JI
  • Takeda, FR
  • Kidane, B
  • Guevara, CR
  • Harustiak, T
  • Bekele, A
  • Kechagias, A
  • Gockel, I
  • Kennedy, A
  • Da Roit, A
  • Bagajevas, A
  • Azagra, JS
  • Mahendran, HA
  • Mejía-Fernández, L
  • Wijnhoven, BPL
  • El Kafsi, J
  • Sayyed, RH
  • Sousa, M
  • Sampaio, AS
  • Negoi, I
  • Blanco, R
  • Wallner, B
  • Schneider, PM
  • Hsu, PK
  • Isik, A
  • Gananadha, S
  • Wills, V
  • Devadas, M
  • Duong, C
  • Talbot, M
  • Hii, MW
  • Jacobs, R
  • Andreollo, NA
  • Johnston, B
  • Darling, G
  • Isaza-Restrepo, A
  • Rosero, G
  • Arias-Amézquita, F
  • Raptis, D
  • Gaedcke, J
  • Reim, D
  • Izbicki, J
  • Egberts, JH
  • Dikinis, S
  • Kjaer, DW
  • Larsen, MH
  • Achiam, MP
  • Saarnio, J
  • Theodorou, D
  • Liakakos, T
  • Korkolis, DP
  • Robb, WB
  • Collins, C
  • Murphy, T
  • Reynolds, J
  • Tonini, V
  • Migliore, M
  • Bonavina, L
  • Valmasoni, M
  • Bardini, R
  • Weindelmayer, J
  • Terashima, M
  • White, RE
  • Alghunaim, E
  • Elhadi, M
  • Leon-Takahashi, AM
  • Medina-Franco, H
  • Lau, PC
  • Okonta, KE
  • Heisterkamp, J
  • Rosman, C
  • van Hillegersberg, R
  • Beban, G
  • Babor, R
  • Gordon, A
  • Rossaak, JI
  • Pal, KMI
  • Qureshi, AU
  • Naqi, SA
  • Syed, AA
  • Vicente, CS
  • Leite, J
  • Freire, J
  • Casaca, R
  • Costa, RCT
  • Scurtu, RR
  • Mogoanta, SS
  • Bolca, C
  • Constantinoiu, S
  • Sekhniaidze, D
  • Bjelovic, M
  • So, JBY
  • Gacevski, G
  • Loureiro, C
  • Pera, M
  • Bianchi, A
  • Moreno, GM
  • Fernández, JM
  • Carrera, MST
  • Vallve-Bernal, M
  • Pascual, MAC
  • Elmahi, S
  • Halldestam, I
  • Hedberg, J
  • Mönig, S
  • Gutknecht, S
  • Tez, M
  • Guner, A
  • Tirnaksiz, MB
  • Colak, E
  • Sevinç, B
  • Hindmarsh, A
  • Khan, I
  • Khoo, D
  • Byrom, R
  • Gokhale, J
  • Wilkerson, P
  • Jain, P
  • Chan, D
  • Robertson, K
  • Iftikhar, S
  • Skipworth, R
  • Forshaw, M
  • Higgs, S
  • Gossage, J
  • Nijjar, R
  • Viswanath, YKS
  • Turner, P
  • Dexter, S
  • Boddy, A
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  • Lopes, LR
  • Tercioti, V
  • Coelho, JD
  • Ferrer, JAP
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  • Tan, L
  • Srinathan, S
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  • Yeung, J
  • Allison, F
  • Carroll, P
  • Vargas-Barato, F
  • Gonzalez, F
  • Ortega, J
  • Nino-Torres, L
  • Beltrán-García, TC
  • Castilla, L
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  • Bastidas, A
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  • Cortes, N
  • Cetares, C
  • Caceres, S
  • Duarte, S
  • Pazdro, A
  • Snajdauf, M
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  • Mortensen, PB
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  • Morten, B
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  • Ainswort, AP
  • Stilling, NM
  • Eckardt, J
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  • Siemsen, M
  • Brandt, B
  • Nega, B
  • Teferra, E
  • Tizazu, A
  • Kauppila, JH
  • Koivukangas, V
  • Meriläinen, S
  • Gruetzmann, R
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  • Weber, G
  • Golcher, H
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  • Kreuser, N
  • Albanese, G
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  • Bianchini, S
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  • Asti, E
  • Bernardi, D
  • Merigliano, S
  • Provenzano, L
  • Scarpa, M
  • Saadeh, L
  • Salmaso, B
  • De Manzoni, G
  • Giacopuzzi, S
  • La Mendola, R
  • De Pasqual, CA
  • Tsubosa, Y
  • Niihara, M
  • Irino, T
  • Makuuchi, R
  • Ishii, K
  • Mwachiro, M
  • Fekadu, A
  • Odera, A
  • Mwachiro, E
  • AlShehab, D
  • Ahmed, HA
  • Shebani, AO
  • Elhadi, A
  • Elnagar, FA
  • Elnagar, HF
  • Makkai-Popa, ST
  • Wong, LF
  • Tan, YR
  • Thannimalai, S
  • Ho, CA
  • Pang, WS
  • Tan, JH
  • Basave, HNL
  • Cortes-Gonzalez, R
  • Lagarde, SM
  • van Lanschot, JJB
  • Cords, C
  • Jansen, WA
  • Martijnse, I
  • Matthijsen, R
  • Bouwense, S
  • Klarenbeek, B
  • Verstegen, M
  • van Workum, F
  • Ruurda, JP
  • van der Sluis, PC
  • de Maat, M
  • Evenett, N
  • Johnston, P
  • Patel, R
  • MacCormick, A
  • Young, M
  • Smith, B
  • Ekwunife, C
  • Memon, AH
  • Shaikh, K
  • Wajid, A
  • Khalil, N
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  • Nasir, I
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  • Baig, M
  • Noor, MA
  • Ahmed, HH
  • Naeem, A
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  • Bernardes, A
  • Campos, JC
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  • Ramos, P
  • Cabral, F
  • Gomes, MP
  • Martins, PC
  • Correia, AM
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  • Ioannidi, L
  • Blackshaw, G
  • Havard, T
  • Escofet, X
  • Powell, A
  • Owera, A
  • Rashid, F
  • Jambulingam, P
  • Padickakudi, J
  • Ben-Younes, H
  • Mccormack, K
  • Makey, IA
  • Karush, MK
  • Seder, CW
  • Liptay, MJ
  • Chmielewski, G
  • Rosato, EL
  • Berger, AC
  • Zheng, R
  • Okolo, E
  • Singh, A
  • Scott, CD
  • Weyant, MJ
  • Mitchell, JD
  • Oesophago-Gastric Anastomotic

Unidades de investigação

Abstract

Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method: This international multi-center prospective study across 137 hospitals in 41 countries included patients who underwent an esophagectomy for esophageal cancer, with 90-day follow-up. The main explanatory variable was country income, defined according to the World Bank Data classification. The primary outcome was 90-day postoperative mortality, and secondary outcomes were composite leaks (anastomotic leak or conduit necrosis) and major complications (Clavien-Dindo Grade III-V). Multivariable generalized estimating equation models were used to produce adjusted odds ratios (ORs) and 95% confidence intervals (CI95%). Results: Between April 2018 to December 2018, 2247 patients were included. Patients from HIC were more significantly older, with higher ASA grade, and more advanced tumors. Patients from LMIC had almost three-fold increase in 90-day mortality, compared to HIC (9.4% vs 3.7%, p < 0.001). On adjusted analysis, LMIC were independently associated with higher 90-day mortality (OR: 2.31, CI95%: 1.17-4.55, p = 0.015). However, LMIC were not independently associated with higher rates of anastomotic leaks (OR: 1.06, CI95%: 0.57-1.99, p = 0.9) or major complications (OR: 0.85, CI95%: 0.54-1.32, p = 0.5), compared to HIC. Conclusion: Resections in LMIC were independently associated with higher 90-day postoperative mortality, likely reflecting a failure to rescue of these patients following esophagectomy, despite similar composite anastomotic leaks and major complication rates to HIC. These findings warrant further research, to identify potential issues and solutions to improve global outcomes following esophagectomy for cancer. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Dados da publicação

ISSN/ISSNe:
1532-2157, 0748-7983

EJSO  W.B. Saunders Ltd

Tipo:
Article
Páginas:
1481-1488
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 16

Citações Recebidas na Scopus: 25

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Keywords

  • Global surgery; Esophagectomy; Anastomotic leak; Postoperative mortality

Proyectos asociados

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Investigador Principal: José Adelino Lobarinhas Barbosa

Estudo Clínico Académico (Chemotherapy) . 2020

Health related Quality of Life six years after bariatric surgery: factors influencing outcome

Investigador Principal: André Manuel Costa Pinho

Estudo Clínico Académico . 2020

Qualidade de vida pós-cirurgica e resultados no tratamento da acalásia

Investigador Principal: José Adelino Lobarinhas Barbosa

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