Influence of E-cadherin genetic variation in canine mammary tumour risk, clinicopathological features and prognosis

Data de publicação:

Autores da FMUP

  • Rui Manuel De Medeiros Melo Silva

    Autor

Participantes de fora da FMUP

  • Canadas, A
  • Santos, M
  • Dias-Pereira, P

Abstract

E-cadherin is a cell adhesion molecule that participates in several cellular processes that guarantee the maintenance of structural and functional integrity of epithelial tissues. E-cadherin plays an important role in mammary carcinogenesis, and various studies have demonstrated the effect of CDH1 genetic variation in risk, progression and biological behaviour of human breast cancer. Although there are some recognized genetic variations in canine CDH1 gene, their influence in canine mammary tumour development and progression has not been previously evaluated. In this study, we aim to assess the influence of CDH1 SNPs rs850805755, rs852280880 and rs852639930 in the risk, clinicopathological features and clinical outcome of canine mammary tumours. A case-control study was conducted involving 206 bitches with mammary tumours and 161 bitches free of mammary neoplasia. CDH1 SNPs rs850805755 and rs852280880 were associated with a decreased risk and a later onset of mammary tumour development. Furthermore, these SNPs were related to the development of small size carcinomas, of low histological grade and low nuclear pleomorphism. SNP rs852639930 was associated with the development of small size tumours with a non-infiltrative, non-invasive growth pattern. Data from the present investigation demonstrate that these CDH1 genetic variants could have a protective role in canine mammary tumours, by being associated with low risk of tumour development, delayed onset of the disease and less aggressive clinicopathological features.

Dados da publicação

ISSN/ISSNe:
1476-5829, 1476-5810

Veterinary and Comparative Oncology  Wiley-Blackwell Publishing Ltd

Tipo:
Article
Páginas:
489-496

Citações Recebidas na Web of Science: 9

Documentos

  • Não há documentos

Métricas

Filiações mostrar / ocultar

Keywords

  • canine mammary tumour; CDH1 gene; E-cadherin; risk; SNP

Proyectos asociados

Previsão das readmissões dos doentes à Urgência Pediátrica: aplicação das técnicas de aprendizagem supervisionadas.

Investigador Principal: Rui Manuel de Medeiros Melo Silva

Estudo Observacional Académico (UrgPediatr) . 2019

Characterization of Pain and Genetic Variants Associated with Pain in Patients with Metastatic Bone Disease

Investigador Principal: Rui Manuel de Medeiros Melo Silva

Estudo Clínico Académico . 2019

Citar a publicação

Partilhar a publicação