Portal de investigação
Insights on ErbB glycosylation - contributions to precision oncology
Autores da FMUP
Participantes de fora da FMUP
- Duarte, HO
- Gomes, J
Abstract
Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region undergoes extensive post-translational glycosylation, which crucially impacts receptor structure, functionality, and therapeutic response, thereby hindering efforts towards the successful translation of such molecular insights into the clinical setting. The unraveling of the ErbB site-specific glycome will allow for the design of more efficient ErbB-directed therapeutic strategies capable of circumventing molecular resistance, the establishment of novel prognostic and predictive clinical biomarkers supporting improved patient stratification, and the rational guidance of therapeutic decisions.
Dados da publicação
- ISSN/ISSNe:
- 2405-8033, 2405-8033
- Tipo:
- Review
- Páginas:
- 448-455
Trends in Cancer CELL PRESS
Citações Recebidas na Web of Science: 8
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- Não há documentos
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Financiamento
Proyectos asociados
Expression of Thomsen-Friedenreich Antigen in colorectal cancer and association with microsatellite instability
Investigador Principal: Celso Albuquerque Reis
Estudo Clínico Académico . 2021
Citar a publicação
Duarte HO,Reis CA,Gomes J. Insights on ErbB glycosylation - contributions to precision oncology. Trends Cancer. 2022. 8(6):p. 448-455. IF:18,400. (1).
