Insights on ErbB glycosylation - contributions to precision oncology

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Celso Albuquerque Reis

    Autor

Participantes de fora da FMUP

  • Duarte, HO
  • Gomes, J

Abstract

Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region undergoes extensive post-translational glycosylation, which crucially impacts receptor structure, functionality, and therapeutic response, thereby hindering efforts towards the successful translation of such molecular insights into the clinical setting. The unraveling of the ErbB site-specific glycome will allow for the design of more efficient ErbB-directed therapeutic strategies capable of circumventing molecular resistance, the establishment of novel prognostic and predictive clinical biomarkers supporting improved patient stratification, and the rational guidance of therapeutic decisions.

Dados da publicação

ISSN/ISSNe:
2405-8033, 2405-8033

Trends in Cancer  CELL PRESS

Tipo:
Review
Páginas:
448-455

Citações Recebidas na Web of Science: 8

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Financiamento

Proyectos asociados

Expression of Thomsen-Friedenreich Antigen in colorectal cancer and association with microsatellite instability

Investigador Principal: Celso Albuquerque Reis

Estudo Clínico Académico . 2021

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